High Content 99 Weight Loss Sibutramine Satiety Strong

High Content Of 99 Sibutramine Satiety Strong Weight Loss Material Quality Assurance

1. Product title:Sibutramine

2. Sibutramine parameter table:

CAS no. : 106650-56-0

Molecular formula: C17H26ClN

Molecular weight: 279.84800

Accurate quality: 279.17500

PSA: 3.24000

LogP: 4.73800

Physical and chemical properties: white crystalline powder

Sibutramine main functions:

Sibutramine is indicated for obesity that cannot be reduced or controlled by exercise and dietary control, and can reduce and maintain weight loss. It should be combined with a low-calorie diet and exercise. It is recommended that obese patients have a body mass index greater than or equal to 30kg/m or greater than or equal to 27kg/m with other risk factors (e.g., diabetes, dyslipidemia, etc.).

Pharmacokinetics of sibutramine:

Sibutramine was effective after 8 weeks of oral administration, and weight loss was achieved at 6 months. The effect of repeated administration lasted for 12 months. The peak time of sibutramine was 1.2h after oral administration, and the peak time of metabolites M1 and M2 was 3 ~ 4h. Oral bioavailability was 77%. Food can reduce the concentration of M1 and M2 metabolites and delay the peak time, but the area under the curve of M1 and M2 does not change significantly, so the effect of food on drugs can be ignored. The protein binding rates of sibutramine, M1 and M2 were 97%, 94% and 94%, respectively. Concentrations in liver and kidney after administration. Sibutramine undergoes a large amount of primary metabolism in the liver to form two active metabolites M1 and M2. M1 and M2 are further metabolized into inactive M5 and M6. The oral clearance rate was 1 750L/h. The half-life of the mother drug was 1.1h, and the half-life of the metabolites M1 and M2 was longer, about 14 ~ 16h. 77% were excreted by kidney, about 8% were excreted by feces, and the metabolites M5 and M6 were excreted mainly by kidney.

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