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GW-501516 Active Pharmaceutical Ingredient API CAS 317318-70-0 PPARδ Agonist

GW-501516 Active Pharmaceutical Ingredient API CAS 317318-70-0 PPARδ Agonist

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    CAS 317318-70-0 PPARδ Agonist

    ,

    GW-501516 Active Pharmaceutical Ingredient API

    ,

    GW-501516 PPARδ Agonist

  • Product Name
    GW-501516
  • CAS No
    317318-70-0
  • Molecular Formula
    C21H18F3NO3S2
  • Density
    1.4±0.1 G/cm3
  • Molecular Weight
    453.498
  • Melting Point
    134-136°C
  • Boiling Point
    584.5±60.0 °C At 760 MmHg
  • Point Of Flammability
    307.3±32.9 °C
  • Storage
    Cool Dry Place
  • Shelf Life
    2 Years
  • Place of Origin
    India
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
    1KG
  • Price
    To discuss
  • Packaging Details
    1KG/25KG
  • Delivery Time
    2
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability
    2000000

GW-501516 Active Pharmaceutical Ingredient API CAS 317318-70-0 PPARδ Agonist

GW-501516 Active Pharmaceutical Ingredient API CAS 317318-70-0 PPARδ Agonist

 

1,  Product title: GW-501516

 

2, GW501516 Description:


GW 501516 (or Cardarine) is a research chemical developed in the 1990s, in order to prevent and cure tumor formation in the colon, prostate, and breasts. Studies done in the early 2000s have found that GW 501516 and other PPAR agonists have also been able to stop metabolic disorders such as obesity and diabetes through specific gene expressions.

As research continued to grow, bodybuilders quickly caught on to GW 501516, calling it the ultimate endurance enhancing supplement. GW's ability to burn off excess fatty tissue, enhance recovery, and dramatically increase endurance has made this product a staple in every athlete's cycle and PCT. With no harmful side effects found in the past 20 years, no wonder why GW 501516 has become a legend in the world of sports and athleticism.


GW 501516 is extremely popular and is extremely effective. The effects it has on increased endurance and fat loss have been staggering.GW has shown to have drastic effects and little to no side effects. It is a favorite amongst many users and offers several great benefits.

GW 501516 can be ran in 8 week cycles, but as with any other steroid or supplement, it should be cycled properly to avoid any possible side effects and the keep it as effective as possible.

 

3,  Product parameter table:

 

Product Name GW-501516 CAS No 317318-70-0
The molecular weight 453.498 Molecular formula C21H18F3NO3S2
density 1.4±0.1 g/cm3 /cm3 boiling point 584.5±60.0 °C at 760 mmHg
point of flammability 307.3±32.9 °C melting point 134-136°C
Shelf Life 2 Years Storage Cool Dry Place

 

4,GW-501516 In vitro studies:


GW 501516 proved to be the most effective and selective PPARα agonist with an EC50 of 1.1 nM against PPARα and a 1000-fold selectivity against other human subtypes of PPARα and -γ [1]. GW 501516 exerts anti-inflammatory effects in mouse cultured proximal tubule (mProx) cells. GW 501516 inhibited the increase of McP-1 mRNA expression induced by palmitic acid and TNFα in a dose-dependent manner [3].


5,GW-501516 In vivo study:


GW 501516 resulted in impaired bone formation, resulting in reduced BMD and deterioration of bone properties in OVX rats [2]. GW 501516 reduced interstitial inflammation and proximal renal tubular cell damage in a protein overload mouse nephropathy model [3]. GW 501516 treatment increased running endurance and the proportion of SUCCinate dehydrogenase (SDH) positive muscle fibers in trained and untrained mice [4].


6,GW-501516 Cell experiment:


GW 501516 was dissolved in DMSO. The cells were starved by incubating in 0.2% FCS DMEM for 9 h, then pre-incubated with GW 501516 at a final concentration of 2.5 and 5μM, or 0.05% DMSO as control for 3 h, followed by stimulation with 150μM palmitate for 12 h to reach 8.0% BSA [3].

GW-501516 Active Pharmaceutical Ingredient API CAS 317318-70-0 PPARδ Agonist 0
7,GW-501516 Experiments on animals:


Rats: 12-week-old female Sprague Dawley rats were assigned to sham operation group and 3 OVX groups. High dose GW 501516 (OVX-GW5), low dose GW 501516 (OVX-GW1) and control group (OVX-CTR). Animals received GW 501516 or carrier (methylcellulose) daily by tube feeding for 4 months. Bone mineral density (BMD) was assessed by dual X-ray absorbance assays of femur, spine, and whole body [2]. Mice: Mice were randomly assigned to different groups and received therapeutic diet and treatment. Rodent diet containing GW 501516 was prepared by uniformly adding GW 501516 to the control diet until the final concentration was 0.04% W/W. In the control diet, 10% of total calories came from fat (5.5% from soybean oil and 4.5% from lard) [3].

 

7, GW-501516 Application:

 

Cardarine (GW-501516) binds to the PPAR receptor, specifically a group of nuclear receptors that initiates the PGC-1a enzyme. This action leads to gene expression, specifically genes that revolve around energy expenditure.

 

Studies involving GW-501516 have shown to increase the metabolism of fatty acids in rats. It was also shown in the same studies to reduce the odds of obesity despite poor eating habits as well as prevent Type-2 diabetes. Cardarine was also shown to increase HDL (good cholesterol) and decrease LDL (bad cholesterol) in a study using monkeys. The effects seemed to hold true with or without exercise.

 

8, GW-501516  picture:

GW-501516 Active Pharmaceutical Ingredient API CAS 317318-70-0 PPARδ Agonist 1