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Acardiaxine API Purity 99 Manufacturer Direct Sales 1kg/25kg

Acardiaxine API Purity 99 Manufacturer Direct Sales 1kg/25kg

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    Aicar 2627-69-2

    ,

    Aicar Sexual Enhancement Powder

    ,

    2627-69-2 aicar powder

  • Product Name
    Aicar
  • CAS No
    2627-69-2
  • The Molecular Weight
    258.231
  • Molecular Formula
    C9H14N4O5
  • Density
    2.1±0.1 G/cm3
  • Boiling Point
    726.3±60.0 °C At 760 MmHg
  • Point Of Flammability
    393.1±32.9 °C
  • Melting Point
    214-215 °C
  • Shelf Life
    2 Years
  • Storage
    Cool Dry Place
  • Place of Origin
    India
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
    1KG
  • Price
    To discuss
  • Packaging Details
    1KG/25KG
  • Delivery Time
    2
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability
    2000000

Acardiaxine API Purity 99 Manufacturer Direct Sales 1kg/25kg

Acardiaxine API Purity 99 Manufacturer Direct Sales 1kg/25kg

 

1,  Product title: aicar

 

2,  Aicar Description:

 

AICAR (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in, but there are some amazing side effects. Interestingly, AICAR has been shown to protect against ischemic injury. This type of injury is directly related to the restriction of blood to tissues, which can cause insufficient amounts of oxygen and glucose needed to keep the tissue alive. This can lead to thrombosis, embolisms, and vasoconstriction. AICAR can be used as a stabilizing peptide for ischemic episodes, and it can allow for proper blood flow to the myocardium (heart). This function is very interesting, as AICAR could be fundamentally used to treat the heart muscle in the aftermath of a heart attack. This might reduce the possibility for ischemic injuries. Abnormal growths of heart tissues and heart valve function have also been altered in animal studies that used the peptide AICAR, which is a downside.

 

3,  Product parameter table:

 

Product Name aicar CAS No 2627-69-2
The molecular weight 258.231 Molecular formula C9H14N4O5
density 2.1±0.1 g/cm3 boiling point 726.3±60.0 °C at 760 mmHg
point of flammability 393.1±32.9 °C melting point 214-215 °C
Shelf Life 2 Years Storage Cool Dry Place

Acardiaxine API Purity 99 Manufacturer Direct Sales 1kg/25kg 0

4,  Aicar Dosage:

 

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

 

5, Aicar contraindications:

 

Antitumor endocrine drugs should be administered under the guidance of experienced professional doctors.
It is not suitable for patients with diabetes complicated with infection and uncontrolled.
This product is not allowed in severe allergic cases.

 

6,In vitro studies:


HepG2 cells were treated with different concentrations of AICAR (0.1-1.0mm) for 12,24 and 48 h. IR-β expression levels were significantly reduced at 0.25,0.5 and 1.0mM AICAR from 48 h to 50%, 53% and 46% of the control group [1].


7,In vivo study:


A 14-week-old male with lean meat (L; 31.3g body weight) wild-type ANDOB/OB (O; 59.6g body weight) mice were injected with amP-activated kinase (AMPK) activator AICAR (A) 0.5mg/g/day or saline control (C) for 14 days. Twenty-four hours after the last injection (including a 12-hour fast), all mice were killed and the flexor plantar complex muscles (gastrocnemius, soleus, and plantar muscles) were excised for analysis. OC (159±12 mg) had lower muscle mass than LC, LA and OA (176±10,178±9 and 166±16 mg, respectively), and was not associated with body weight change [2]. Kidney weight was significantly higher in the untreated group compared with the exercise and AICAR (0.5mg/g body weight) groups. The heart weight of the exercise group was higher than that of the other groups, while the liver weight of the AICAR group was significantly higher than that of the exercise group and the untreated group [3].

 


8,Cell experiment:


HepG2 cells (5×10 5 cells) were inoculated in 6-well culture plates and then cultured in serum-free medium for 12 hours before transfection. 1 μ g plasmid was transfected with FuGENE6 transfection reagent. 5 h after transfection, the medium was removed and added to each well with or without AICAR (0.1-1.0mm). The stimulation medium was changed every 24 hours [1].
Experiments on animals
Mice [2] were 14-week-old lean (Lepob / + or Lepob / +) and OB/OB (Lepob/Lepob) male mice. After 14 days of experimental treatment (24 hours after AICAR injection, including 12 hours of fasting), the flexor plantar complex was removed clean (tendin-tendon) from 4% isoflurane anesthetised mice. The muscles were quickly weighed and then histologically treated or frozen in liquid nitrogen and stored at -80℃. The anesthetized mice were killed by diaphragmatic transects and removal of the entire heart while breathing 4% isoflurane after blood was taken directly through the heart by needling. AICAR or saline (control) is injected subcutaneously into the lateral distal portion of the back. AICAR was given 0.5mg/g once daily for 14 days. Saline (control) was injected in the same manner as AICAR and in the same dosage as AICAR. Weigh yourself before you die. Rats [3] Male 5-week-old ZDF rats were subcutaneously injected with a single dose of AICAR (0.5 mg/g body weight) or underwent one treadmill run (60 min, 25 m/min) with 5% incline. Untreated ZDF rats were used as controls (n = 5 for each group). The rats were killed by cervical dislocation 1 hour after subcutaneous AICAR injection or immediately after running on a treadmill. To avoid any effects of muscle spasms and hypoxia, the red and white gastrocnemius muscles were removed within a few seconds and immediately frozen clamped for subsequent determination of AMPK activity.

 

9,Aicar The picture

Acardiaxine API Purity 99 Manufacturer Direct Sales 1kg/25kg 1