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CAS 139755-83-2 Sildena Non White Powder Manufacturer Direct Supply Quality Assurance

CAS 139755-83-2 Sildena Non White Powder Manufacturer Direct Supply Quality Assurance

  • High Light

    CAS 1270138-40-3 Active Substance

    ,

    NSI-189 Antidepressant Active Substance

    ,

    99% Antidepressant Active Substance

  • Product Name
    Sildenafil
  • Brand Name
    Kan Ying
  • Purity
    99%
  • Molecular Formula
    C22H30N6O4S
  • Molecular Weight
    474.576
  • Appearance
    White Powder
  • CAS No
    139755-83-2
  • Shelf Life
    2 Years
  • Place of Origin
    India
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
    1kg
  • Price
    To discuss
  • Packaging Details
    1kg-25kg
  • Delivery Time
    2
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability
    200000

CAS 139755-83-2 Sildena Non White Powder Manufacturer Direct Supply Quality Assurance

CAS 139755-83-2 Sildena Non White Powder Manufacturer Direct Supply Quality Assurance​

 

1. Product title:Sildenafil

 

Sildenafil, a phosphodiesterase 5 (PDE-5) inhibitor with an IC50 of 5.22 nM, is probably the best compound for erectile dysfunction.

 

2. Product parameter table:

 

product name Sildenafil
CAS 139755-83-2
Density of 1.4±0.1 g/cm3
Boiling point 672.4ºC at 760 mmHg
Melting point 187-189°C
Molecular formula C22H30N6O4S
Molecular weight 474.576
Flash point 360.5ºC
Precise quality 474.204926
PSA 121.80000
LogP 2.27
Appearance White crystalline powder
Vapor pressure 6.1E-18mmHg at 25°C
Refractive index 1.665
storage Refrigerator
molecular structure

1. Molar refractive index: 126.02

2. Molar volume (CM3 /mol) : 339.4

3, equal tension specific volume (90.2K) : 922.1

4. Surface tension (DYNE /cm) : 54.4

5, polarization (10-24cm3) : 49.96

 

 

3.Description:

 

Sildenafil, commonly known by its commercial name Viagra (Viagra in China, Viagra in Taiwan and Hong Kong), is an erectile dysfunction drug accidentally invented while developing a treatment for cardiovascular disease. But sildenafil is more widely used and influential in China than the trade name "Wei Ge". Because Pfizer has a patent on sildenafil, its viagra, made from the citrate of ezedenafil, is the only drug currently on the market that is legally used as the main ingredient.

 

This product is an oral medication for erectile dysfunction (ED). It is the citrate of sildenafil, a selective inhibitor of type 5 phosphodiesterase (PDE5) specific to cyclic guanosine phosphate (cGMP). Mechanism of action: The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the penile sponge during sexual stimulation. NO activation of guanosine cyclase leads to increased levels of cyclic guanosine phosphate (cGMP), which relaxes smooth muscles and fills blood in sponges.

 

Efficacy of Sildenafil on erection response: Sildenafil (Viagra) is a highly selective phosphatidiesterase 5(PDE5) inhibitor. PDE5 is highly expressed in the cavernosa of the penis, but low in other tissues (including platelets, blood vessels, visceral smooth muscle, and skeletal muscle). Sildenafil leads to relaxation of the smooth muscle of the cavernosa by selectively inhibiting PDE5, enhancing the nitric oxide (NO) -CGMP pathway, and elevating the level of cGMP, leading to a natural erectile response to sexual stimulation in erectile dysfunction patients. Erectile response generally increases with sildenafil dose and plasma concentration. Experiments showed that the effect lasted up to 4 hours, but the reaction was weaker than 2 hours. Sildenafil response to myocardium: PDE5 does not exist in normal or pathological cardiac conduction tissues, myocardium cells, endothelial cells, and lymphatic tissues, so sildenafil (PDE5 inhibitor) has no positive inotropic effect and cannot directly affect myocardial systolic function.

CAS 139755-83-2 Sildena Non White Powder Manufacturer Direct Supply Quality Assurance 0

Effect of sildenafil on cardiac parameters: a single dose of sildenafil 100mg in normal male volunteers showed no clinically significant ecg changes. Eight patients with stable ischemic heart disease received sildenafil 40mg intravenously in 4 doses monitored by a swan-ganz catheter. Systolic and diastolic blood pressure at rest decreased by 7% and 10%, respectively, from baseline. Resting right atrium, pulmonary artery pressure, pulmonary wedge pressure and cardiac output decreased by 28%, 28%, 20% and 7%, respectively. Although this intravenous dose was two to five times higher than the average peak plasma concentration of 100mg for a single oral dose of sildenafil in healthy male volunteers, these hemodynamic responses persisted during exercise.

 

Sildenafil response to blood pressure: in healthy men, a single dose of sildenafil 100mg resulted in a decrease in supine bp (with a mean maximum of 8.4/5.5mmHg), most significant at 1 to 2 hours after administration, with no difference from placebo at 8 hours after administration. Sildenafil 25mg, 50mg, and 100mg had similar effects on blood pressure and appeared to be independent of dose and blood concentration. Patients who also took nitrates had a greater reduction in blood pressure. Hypotension (90/50 MMHG) and nitrates or nitrate-providing drugs are strict contraindications for sildenafil use. The maximum use of sildenafil for bp occurred approximately 1 h after administration, which was consistent with the drug plasma peak. Thus, sexual activity may induce cardiac events at peak plasma concentrations of sildenafil. Although the hypotensive response to sildenafil is mild and transient (typically bp returns to baseline within 4 hours), the interaction between sildenafil and nitrates can produce a significant and longer duration of bp reduction. Sildenafil has a short half-life and can be eluted within 24 hours (about 6 half-lives). The American College of Cardiology and the American Heart Association have indicated that sildenafil should not be used in the last 24 hours if a nitrate has been used. Effects of sildenafil on vision: Studies have shown no effect on visual acuity, retinal electrogram, intraocular pressure, or visual nipple size when taken at twice the maximum recommended dose. Transient blue/green color discrimination anomalies may be present. Whether used alone or in combination with aspirin, it has no effect on the duration of bleeding. In vitro, the product enhanced the antiplatelet aggregation of sodium nitroprusside (NO donor) in humans. The combination of heparin and sildenafil has an additive effect on prolongation of bleeding time in rabbits under anesthesia, but no similar human studies have been conducted.

 

A single dose of sildenafil 100mg in healthy volunteers did not affect sperm motility and morphology.

 

4.  Pictures of the product:

 

CAS 139755-83-2 Sildena Non White Powder Manufacturer Direct Supply Quality Assurance 1