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Acceleration Cardarine GPPAR Receptor Agonist W501516 CAS 31731

Acceleration Cardarine GPPAR Receptor Agonist W501516 CAS 31731

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    GW501516 Receptor Agonist


    PPAR Receptor Agonist


    Acceleration Cardarine Receptor Agonist

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Acceleration Cardarine GPPAR Receptor Agonist W501516 CAS 31731

1. Product title: GW-501516


2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid


2. Product parameter table:


product name GW-501516
Density of 1.4±0.1 g/cm3
Boiling point 584.5±60.0 °C at 760 mmHg
Melting point 134-136°C
Molecular formula C21H18F3NO3S2
Molecular weight 453.498
Flash point 307.3±32.9 °C
Precise quality 453.068024
PSA 112.96000
Log P 6.29
Appearance White solid
Vapor pressure 0.0±1.7 mmHg at 25°C
Refractive index 1.619
Storage conditions Refrigerator
Stability of Light Sensitive
Water solubility DMSO: soluble20mg/mL, clear


3. Product introduction:


W-501516 is a unique drug officially classified as a PPAR receptor agonist (PPAR-RA) commonly marketed under the name Cardarine. Research on the drug began in 1992 as a joint venture between GlaxoSmithKline of Britain and Ligand Pharmaceuticals. The product was studied as a treatment for a variety of cardiovascular diseases as well as diabetes, obesity and other conditions, but researchers quickly found that PPAR-RA was very effective in improving endurance.


Cardarine(GW-501516) binds to PPAR receptors, specifically a group of nuclear receptors that initiate pgC-1A enzymes (sensors that detect thyroid and steroid hormones in the body). This behavior leads to gene expression, particularly around energy expenditure.


Studies involving GW-501516 have shown an increase in fatty acid metabolism in laboratory mice. In studies using monkeys, gW-501516 use data also showed an increase in HDL(good cholesterol) and a decrease in LDL(bad cholesterol), with or without exercise. Gw-501516 will play its effect significantly.


The GW-501516 is so effective that it is a popular product for pre-competition athletes. Increasing muscle endurance is the most incredible effect of PPAR-RA, and those using THE GW-501516 will find their endurance greatly improved, won't tire out easily, and will be able to train harder. The increase in cardiovascular endurance brought about by GT-501516 is significant and has been shown to eliminate problems such as reduced endurance caused by the effects of the anabolic steroid troblone on the heart. Many people on Jumbolon report that their breathing becomes a little more difficult, so doing aerobics on jumbolon becomes a more difficult task. When jumbolon is used, the GT-501516 can eliminate this negative effect.


The effect of GW-501516 also helps a lot with fat loss, so you can do aerobic exercise more intensely and for longer. In addition, it does not have any of the catabolic effects associated with many fat-reducing drugs, meaning GW501516 does not cause muscle loss during fat loss, and GW-501516 has been shown to increase nutrient utilization efficiency, greatly increasing the body's ability to absorb food intake. People using GW-501516 will see an increase in glucose intake and a decrease in body fat storage.


4.product description:


GW501516 is subtype-selective small-molecule agonist of Peroxisome proliferator-activated receptor δ (PPARδ) with Ki The value of 1.1 nM [1].


GW501516 is discovered by combinatorial chemistry and structure-based drug design to use as an ideal chemical tool to The function of ubiquitously expressed PPARδ In the cell-based transfection assay, It induces expression of a gal4-responsive reporter gene with EC50 value of 1.2 nm. GW501516 shows more than 1000-fold Selective expression of PPARδ over other subtypes. PPARδ is expressed in many tissues that contribute to cholesterol flux. And is a RXR of partner. As an agonist of PPARδ, GW501516 is found to increase the expression of ABCA1 as well as the apoA1-specific cholesterol efflux. In primate model of human metabolic disease,GW501516 increases the level of HDLc and lowers the fasting triglycerides. GW501516 also produces fewer, yet larger, LDL and VLDL particles results in a less atherogenic lipid composition. Furthermore, GW501516 partially corrects the hyperinsulinemia in primates without adverse effects on glycemic control [1, 2].


5. References:


[1] Wei ZL, Kozikowski AP. A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta. J Org Chem. 2003 Nov 14; 68 (23) : 9116-8.

[2] Oliver WR Jr, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001 Apr 24; 98 (9) : 5306-11.


6. Pictures of the product:



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