Thiamphenicol Off white solid Respiration, urinary, liver and gallbladder, typhoid fever
1. Product title: Thiamphenicol
2. Product parameter table:
Product Name |
Thiamphenicol
|
Specification |
99% |
Appearance |
Off-white solid |
Main Effect |
It is an antibiotic, a methylsulfonyl analog of chloramphenicol |
Brand Name |
Kan Ying |
Store-method |
Cool Dry Place |
Shelf Life |
2 Years When
Properly Stored |
From |
India |
3. Product introduction:Thiamphenicol is white to off-white crystalline powder or crystals. Melting point (℃) 178-180 (mixed rotation), 164-166 (right rotation). Its chemical formula is [R-(R*,R*)]N-[1-(hydroxymethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]-2,2 -Dichloroacetamide, easily soluble in dimethylformamide, slightly soluble in absolute ethanol, slightly soluble in water. Clinically, it is mainly used to treat respiratory, urinary, hepatobiliary, typhoid and other diseases such as intestinal surgery, obstetrics and gynecology and ENT infections, especially for mild to moderate infections.
4. Chemical and physical properties of Thiamphenicol:
Density 1.5±0.1 g/cm3
Boiling point 695.9±55.0 °C at 760 mmHg
Melting point: 163-166ºC
Molecular formula C12H15Cl2NO5S
Molecular weight 356.222
Flash point 374.7±31.5 °C
Exact quality 355.004791
PSA 112.08000
LogP -0.27
Appearance traits off-white solid
Vapor pressure 0.0±2.3 mmHg at 25°C
Refractive index 1.583
Molecular Structure
5. Molecular properties data:
1. Molar refractive index: 79.78
2. Molar volume (m3/mol): 238.7
3. Isotonic specific volume (90.2K): 661.0
4. Surface tension (dyne/cm): 58.7
5. Polarizability (10-24cm3): 31.62
Computational Chemistry
1. Hydrophobic parameter calculation reference value (XlogP): none
2. Number of hydrogen bond donors: 3
3. Number of hydrogen bond acceptors: 5
4. Number of rotatable chemical bonds: 6
5. Number of tautomers: 2
6. Topological molecular polar surface area 112
7. Number of heavy atoms: 21
8.Surface charge: 0
9. Complexity: 443
10. Number of isotope atoms: 0
11.Determine the number of atomic stereo centers: 2
12. Uncertain the number of atomic stereo centers: 0
13. Determine the number of chemical bond stereo centers: 0
14. Uncertain the number of chemical bond stereo centers: 0
15.Number of covalent bond units: 1
More
1. Properties: white to almost white crystalline powder or crystal
2. Density (g/mL, 25/4℃): Not determined
3. Relative vapor density (g/mL, air=1): not determined
4. Melting point (ºC): 163-166
5. Boiling point (ºC, normal pressure): not determined
6. Boiling point (ºC, 5.2kPa): not determined
7. Refractive index: not determined
8. Flash point (ºC): not determined
9. Specific rotation (º): not determined
10. Spontaneous ignition point or ignition temperature (ºC): not determined
11. Vapor pressure (kPa, 25ºC): not determined
12. Saturated vapor pressure (kPa, 60ºC): not determined
13. Heat of combustion (KJ/mol): not determined
14. Critical temperature (ºC): not determined
15. Critical pressure (KPa): not determined
16. Logarithmic value of oil-water (octanol/water) partition coefficient: not determined
17. Upper explosion limit (%, V/V): not determined
18. Lower explosion limit (%, V/V): not determined
19. Solubility: not determined
5. Precautions:Use with caution: (1) those with liver dysfunction; (2) those with renal dysfunction; (3) the elderly and infirm.
During the course of treatment, blood routine should be checked regularly. For long-term treatment, the reticulocyte count should be checked to find adverse effects of the blood system in time.
If the white blood cell count tends to decrease, the drug should be stopped immediately.
The excretion of thiamphenicol is reduced in patients with renal insufficiency, and the body may have a tendency to accumulate and should be used in a reduced amount.
The copper sulfate method can be false positive when measuring urine sugar.
During medication, the surrounding whole blood should be checked regularly; for long-term treatment, the reticulocyte count should be checked; if necessary, bone marrow examination should be performed to detect adverse blood system reactions in time.
6. Product pictures :

