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Reduce Blood Glucose Gliquidone White Powder CAS No 33342-05-1

Reduce Blood Glucose Gliquidone White Powder CAS No 33342-05-1

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    Reduce Blood Glucose Gliquidone

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    Gliquidone White Powder

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    CAS No 33342-05-1

  • Product Name
    Gliquidone
  • CAS No
    33342-05-1
  • The Molecular Weight
    527.632
  • Density
    1.3±0.1 G/cm3
  • Molecular Formula
    C27H33N3O6S
  • Melting Point
    179ºC
  • PSA
    130.26000
  • LogP
    3.11
  • Shelf Life
    2 Years
  • Storage
    Cool Dry Place
  • Place of Origin
    India
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
    1KG
  • Price
    To discuss
  • Packaging Details
    1KG/25KG
  • Delivery Time
    2
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability
    2000000

Reduce Blood Glucose Gliquidone White Powder CAS No 33342-05-1

Resistance to diabetes reduce blood glucose gliquidone Oral Hypoglycemic Agents

 

*   Product title:gliquidone

 

*    Product Description: 

 

Gliquantel is the second generation of oral sulfonylurea hypoglycemic agent, which is a highly active islet β cell agent. It binds to the specific receptor on the cell membrane of islet β, and can induce the production of appropriate amount of insulin to reduce the concentration of blood glucose. The product reaches its maximum plasma concentration 2 to 2.5 hours after oral administration and is quickly absorbed completely. Plasma has a half-life of 1.5 hours and is completely metabolized. The metabolites do not have hypoglycemic effects. Most of the metabolites are excreted by the biliary tract digestive system.

 

*   Product parameter table:

 

 

density

1.3±0.1 g/cm3

melting point

179ºC

Molecular formula

C27H33N3O6S

The molecular weight

527.632

 Precise quality

527.208984
PSA 130.26000
LogP 3.11

Appearance

White powder

refractive index

1.624

 

 

*   Drug pharmacokinetics:

 

This product is easily absorbed by oral administration and reaches its peak concentration in blood after 2-3h. It is mainly metabolized in the liver, 95% of the metabolites are excreted through bile and excreted by feces, and less than 5% of the metabolites are excreted through kidney. The half reduction period was 24h, and the plasma protein binding rate was 99%. Hypoglycemia has been reported in all sulfonylureas, especially the hypoglycemia reaction of Youxiangtang is common. If not handled correctly and immediately, it can cause death. This product is well tolerated when taken as prescribed. Rare hypoglycemia reaction, which may be related to the metabolic excretion characteristics of this drug, it is mainly excreted through the liver and gallbladder, only 5% of the excretion through the kidney, so when accompanied by renal function damage, it is not easy to cause drug accumulation and lead to hypoglycemia.

 

*   To adapt to the symptoms:

 

It is suitable for mild and moderate non-insulin-dependent diabetes mellitus with unsatisfactory therapeutic effect of diet alone. The patients have certain insulin-secreting function of islet B cells, and no serious complications. This product has a mild effect, can be adjusted according to the patient's condition, less hypoglycemia reaction, suitable for the diet therapy alone can not be satisfactory control of adult onset diabetes, especially for diabetic patients with renal insufficiency. Ⅱ type type diabetes mellitus with renal dysfunction. Elderly patients over 60 years of age with diabetes. Recurred hypoglycemia with other oral diabetes drugs. Only small amounts of medication are needed to control postprandial hyperglycemia. Other sulfonylurea hypoglycemic drugs are not effective, you can still try to use this product.

 

*   Symptoms of taboo:

 

Insulin - dependent diabetes mellitus, diabetic coma, prediabetic coma, diabetes patients with acidosis and pregnant women are prohibited. See sulfonamide, less adverse reactions than sulfonamide. In particular, only 5% of this product is excreted through the kidney, this product is obviously superior to other sulfonylurea drugs for diabetics with mild to moderate renal insufficiency, and insulin is still more suitable for patients with severe renal insufficiency. It is well tolerated and only a few patients have mild gastrointestinal reactions such as nausea and abdominal distension.

 

*   Adverse reactions:

 

There are very few reports of skin allergic reactions, gastrointestinal reactions, mild hypoglycemia reactions, and changes in the blood system.

 

*    Pictures of the product:

 

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