Zhejiang Kanying Import & Export Co. Ltd 86--17169758851 kanyingexport@gmail.com
Resistance to acid Alleviate stomach Cimetidine  Active Pharmaceutical Ingredient API

Resistance to acid Alleviate stomach Cimetidine Active Pharmaceutical Ingredient API

  • Product Name
    Cimetidine
  • CAS
    51481-61-9
  • The Molecular Weight
    252.339
  • Grade
    Pharmaceutical And Food Grade
  • Purity
    99%
  • Color
    The Color Crystals Have A Light Sulfur Odor
  • Molecular Formula
    C10H16N6S
  • Point Of Flammability
    241.8±31.5 °C
  • Boiling Point
    476.2±55.0 °C At 760 MmHg
  • Place Of Origin
    India
  • Place of Origin
    India
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
    1KG
  • Price
    To discuss
  • Packaging Details
    1KG/25KG
  • Delivery Time
    2
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability
    2000000

Resistance to acid Alleviate stomach Cimetidine Active Pharmaceutical Ingredient API

*   Product title:Cimetidine

 

*   Product Description:

 

Cimetidine is an antacid drug. Commonly used dosage forms include tablet, capsule, oral milk, injection, etc. Used to relieve stomachache, heartburn and acid reflux caused by excessive stomach acid.

 

*   Product parameter table:

 

density

1.3±0.1 g/cm3

boiling point

476.2±55.0 °C at 760 mmHg

melting point

139-144°C

Molecular formula

C10H16N6S

The molecular weight

252.339

point of flammability

241.8±31.5 °C

Precise quality

252.115707
PSA 114.19000
LogP 0.07

Appearance

The white crystals have a light sulfur odor

vapour pressure

0.0±1.2 mmHg at 25°C

refractive index

1.632

storage condition

Store under 2 ° C to 8 ° C

stability

If used and stored according to specifications, it will not decompose and has no known hazardous reaction

Water solubility

0.5 g/100 mL at 20 ºC

calculational chemistry

1. Calculation reference value of hydrophobic parameters (XLOGP) : none

2. Number of hydrogen bond donors :3

3. Number of hydrogen bond receptors :4

4. Number of rotatable bonds :7

5. Number of tautomers :6

6. Topological molecular polar surface area 114

7. Heavy Atoms :17

8. Surface charge :0

9. Complexity :296

10. Number of isotopic atoms :0

11. Determine the number of protosteric centers :0

12. Number of uncertain atomic structuring centers :0

13. Determine the number of chemical bond formation centers :0

14. Uncertain number of bond structuring centers :0

15. Number of covalent bond units :1

 

*   Description of necessary first aid measures:


General Advice
Consult your doctor. Show this safety technical specification to the doctor on site.
The suction
If inhaled, remove victim to fresh air. If you have stopped breathing, give mouth to mouth resuscitation. Consult your doctor.
Skin contact
Rinse with soap and plenty of water. Consult your doctor.
Eye contact
Flush eyes with water as a precaution.
eat
Never feed anything from the mouth of an unconscious person. Rinse your mouth with water. Consult your doctor.

 

*   Matters needing attention:


Cimetidine tablets, cimetidine capsules, cimetidine oral milk:

1. The continuous use of this product shall not exceed 7 days. If the symptoms are not relieved, please consult a physician or pharmacist.

2. Children and elderly patients should use it under the guidance of physicians.

3. Use with caution in the following cases: severe heart and respiratory diseases, systemic lupus erythematosus, organic encephalopathy, liver and kidney function impairment.

4. In case of overdose or serious adverse reactions, seek medical advice immediately.

5. People who are allergic to this product should not use it, and people who are allergic should use it with caution.

6. It is prohibited to use this product when its properties change

7. Please keep this product out of reach of children.

8. Children must be under the supervision of an adult.

9. If you are using other drugs, please consult a physician or pharmacist before using this product.

Cimetidine injection:

1. It is not suitable for acute pancreatitis.

2, attention should be paid to check the renal function and blood routine during medication.

3. It should be avoided to use this product with central anticholinergic drugs at the same time to prevent aggravation of central neurotoxic reaction.

4. Caffeine and caffeine-containing beverages should be prohibited when using this product.

5. Suddenwithdrawal of medication may lead to chronic peptic ulcer perforation, which is estimated to be caused by the high acidity of the rebound after discontinuation. Therefore, the medication should be continued (400mg per night) for 3 months after completion of treatment.

6, interference with the diagnosis: gastric occult blood test can appear false positive; Blood salicylic acid concentration, serum creatinine, prolactin, aminotransferase and other concentrations may increase; Parathyroid hormone concentrations may be reduced.

7. The following situations should be used with caution:

(1) Severe heart and respiratory diseases; Use with caution in patients with liver and renal insufficiency.

(2) Chronic inflammation, such as systemic lupus erythematosus (SLE), may increase the myelotoxicity of cimetidine.

(3) Organic encephalopathy.

(4) Renal function impairment (moderate or severe).

8. Pregnant women and lactating women: this product can pass through the placental barrier and enter the milk, causing fetal and infant liver dysfunction, so it is prohibited.

9. Children's medication: use with caution in children.

10. Elderly medication: use with caution in elderly patients. The interval of medication can be extended, and the dosage should be reduced.

11. Drug overdose:

(1) Common signs of overdose include shortness of breath or dyspnea and tachycardia.

(2) Treatment: First, remove the unabsorbed drugs in the gastrointestinal tract, and give clinical monitoring and supportive therapy. Respiratory respiration should be carried out immediately in patients with respiratory failure, and β-adrenergic blockers should be given in patients with tachycardia.

 

*   Pharmacological effects:


It acts mainly on H2 receptors on parietal cells and plays a competitive role in inhibiting histamine, inhibiting basal gastric acid secretion, as well as gastric acid secretion stimulated by food, histamine gastrin, caffeine, insulin and other stimuli. After injection of 300mg for 4-5 hours, the secretion of basic gastric acid can be inhibited by 80%, and the secretion of basic gastric acid can be inhibited by 50% for 4-5 hours.

 

*   pharmacokinetics:


Cimetidine injection:

After absorption, the product is widely distributed in tissues of the whole body except the brain. It can pass through the placenta barrier, and the concentration of the product in milk can be higher than that in plasma. The protein binding rate is 15%-20%, partly metabolized in the liver, and the metabolites are Sulphoxide and hydroxymethylcimetiding, which are mainly excreted by the kidney. After 24 hours, about 75% of the injection volume was excreted from the kidney in its original form. 10% can be excreted from feces. It can be cleared by hemodialysis. T1/2 was 2 hours for normal renal function, and the half-life (T1/2) was 2.9 hours for 20-50ml/ min, 3.7 hours for 20ml/ min, and 5 hours for renal insufficiency.

 

*   Pictures of the product:

 

Resistance to acid Alleviate stomach Cimetidine  Active Pharmaceutical Ingredient API 0Resistance to acid Alleviate stomach Cimetidine  Active Pharmaceutical Ingredient API 1