1, Product title: Iron dextran
2, Product Description:
Iron dextran, the name of western medicine. Common dosage forms include tablet, granule, capsule, oral liquid, injection and so on. It is an anti-anemia drug. It is used for iron deficiency anemia caused by chronic blood loss, malnutrition, pregnancy, childhood development, etc.
3, Product parameter table:
Molecular formula |
H2O4S.Fe |
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The molecular weight |
1347.364 |
Quality standard |
1346.576050 |
Appearance |
solution |
Storage |
Seal save |
The stability of | This product is a complex of iron and dextran. After intramuscular injection, some of the iron was phagocytized by macrophages and transferred to fibroblasts. The remaining iron was slowly removed from the injected part (50% at 72 hours) and transferred to plasma via lymphocytes. Iron can still be found in the blood 3 weeks after injection. Iron is mainly stored in reticuloendothelial cells of the liver and spleen and is slowly released for hemoglobin synthesis. This absorption pathway is not controlled by the gastrointestinal tract, so the recovery of stored iron is rapid and complete. But the hemoglobin rate was still the same as the oral dosage, averaging about 0.15g per day. Effective for iron deficiency anemia. |
Computational chemistry |
1. Calculation reference value of hydrophobic parameters (XLOGP) : none 2. Number of hydrogen bond donors :2 3. Number of hydrogen bond receptors :4 4. Number of rotatable bonds :0 5. Number of tautomers: none 6. Topological molecular polar surface area 83 7. Number of heavy atoms :6 8. Surface charge :0 9. Complexity :81.3 10. Number of isotopic atoms :0 11. Determine the number of protosteric centers :0 12. Number of uncertain atomic structuring centers :0 13. Determine the number of chemical bond formation centers :0 14. Uncertain number of bond structuring centers :0 15. Number of covalent bond units :2
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more |
1. Properties: dark brown to black amorphous powder
2. Solubility: Soluble in water as a dark brown colloid solution, pH value of 5.2 ~ 6.5, insoluble in ethanol and other organic solvents. |
4, taboo:
1. It is forbidden for people who are allergic to this product.
2. Severe damage to liver and kidney function, especially if accompanied by untreated urinary tract infection, is contraband.
3. It is forbidden for patients with high iron load, hemochromatosis or hemosiderosis.
4. Patients with non-iron deficiency anemia (such as thalassemia) are prohibited.
5, Matters needing attention:
1. It should not be used for a long time. It should be used after being diagnosed as iron deficiency anemia by a physician, and blood and serum iron levels should be checked regularly during treatment.
2. Use with caution in the following cases: alcoholism, hepatitis, acute infection, intestinal inflammation, pancreatitis, gastric and duodenal ulcer, and ulcerative enteritis.
3, children dosage, please consult a physician or pharmacist.
4. This product should not be taken with strong tea.
5. This product should be taken after meals or meals to reduce gastric irritation.
6. In case of overdose or serious adverse reactions, seek medical advice immediately.
7. People who are allergic to this product should not use it, and people with allergy should use it with caution.
8. It is prohibited to use this product when its properties change.
9. Please keep this product out of reach of children.
10. Children must be under the supervision of an adult.
11. If you are using other drugs, please consult a physician or pharmacist before using this product.
6, Drug interaction:
1, dilute hydrochloric acid helps the absorption of the product.
2, vitamin C and this product take together, is conducive to absorption.
3, this product with calcium, phosphate, tetracycline, antacid and tannic acid equivalent to take, can hinder the absorption of iron.
4. This product can reduce the absorption of levodopa, carbidopa, methyldopa and quinolones.
5. If you are taking other drugs, please consult a physician or pharmacist before using this product.
7, Pharmacological effects:
This product is an anti-anemia drug, iron is the main component of hemoglobin and myoglobin; Hemoglobin is the main oxygen carrier in red blood cells. Myoglobin is the part of muscle cells that stores oxygen for use during muscle movement. Most of the enzymes involved in the tricarboxylic acid cycle contain iron or function only in the presence of iron. Therefore, after iron supplementation in patients with iron deficiency, in addition to the acceleration of hemoglobin synthesis, the symptoms related to iron deficiency and reduction of ferrite activity, such as growth retarded, abnormal movement, lack of physical strength, changes in mucous membrane tissue and skin and nail lesions, can also be gradually corrected.
8, Pictures of the product :