antifungal infection Lomefloxacin hydrochloride Antibiotic API Spot good hair
1, Product title:Lomefloxacin hydrochloride
2, Product Description:
Lomefloxacin hydrochloride, the name of western medicine. Common dosage forms include tablets, capsules, dispersible tablets, granules, creams, eye gels, eye drops, and ear drops. Quinolones are antifungal agents. For the following infections caused by sensitive bacteria: respiratory tract infection: acute attack of chronic bronchitis, bronchiectasis with infection, acute bronchitis and pneumonia, etc. Genitourinary system infection, gastrointestinal bacterial infection, abdominal cavity, biliary tract, typhoid fever and other infections, bone and joint infections, skin and soft tissue infections, sepsis and other systemic infections.
3, Product parameter table:
boiling point |
542.7ºC at 760 mmHg |
---|---|
melting point |
290-3000C |
Molecular formula |
C17H20ClF2N3O3 |
The molecular weight |
387.809 |
point of flammability |
282ºC |
Precise quality |
387.116119 |
PSA | 74.57000 |
LogP | 2.99170 |
Appearance |
White powder |
Storage |
Store airtight in a cool, dry warehouse. |
stability |
Stable under normal temperature and pressure, avoid contact with strong oxidant. |
Computational chemistry |
1. Calculation reference value of hydrophobic parameters (XLOGP) : none
2. Number of hydrogen bond donors :3
3. Number of hydrogen bond receptors :8
4. Number of rotatable bonds :3
5. Number of tautomers: none
6. Polar surface area of topological molecules is 72.9
7. Number of heavy atoms :26
8. Surface charge :0
9. Complexity :586
10. Number of isotopic atoms :0
11. Determine the number of protosteric centers :0
12. Uncertain number of atomic structuring centers :1
13. Determine the number of chemical bond formation centers :0
14. Uncertain number of bond structuring centers :0
15. Number of covalent bond units :2 |
4, First aid measures:
Inhalation: Move victim to fresh air, keep breathing, and rest. Seek medical advice if you feel unwell.
Skin Contact: Immediately remove/remove all contaminated clothing. Wash gently with plenty of soap and water.
If skin irritation or rash develops: seek medical attention.
Eye contact: Wash carefully with water for a few minutes. If convenient and easy to operate, remove contact lenses. Continue to wash.
If eye irritation: seek medical attention.
Ingestion: Call a detoxification center/doctor if you feel unwell. Rinse your mouth.
Emergency rescuer protection: Rescuers should wear personal protective equipment, such as rubber gloves and air-tight goggles.
5, indications:
Lomefloxacin Hydrochloride Tablets, Lomefloxacin Hydrochloride Capsules, Lomefloxacin Hydrochloride Dispersible Tablets, Lomefloxacin Hydrochloride Granules: For the following infections caused by sensitive bacteria:
1. Respiratory tract infection: acute attack of chronic bronchitis, bronchiectasis with infection, acute bronchitis and pneumonia, etc.
2. Urogenital system infection: acute cystitis, acute pyelonephritis, complex urinary tract infection, acute onset of chronic urinary tract infection, acute or chronic prostatitis, gonorrhoeae neichoderma urethritis or cervicitis (including those caused by enzyme production strains), etc.
3. Gastrointestinal bacterial infection: caused by Shigella, Salmonella, Enterotoxigenic Escherichia coli, Aeromonas hydrophilica, Vibrio parahaemolyticus, etc.
4, abdominal cavity, biliary tract, typhoid and other infections.
Bone and joint infections.
6, skin and soft tissue infection.
7. Systemic infections such as sepsis.
Other infections such as paranasal sinusitis, otitis media, blepharitis, etc.
Lomefloxacin Hydrochloride Cream: Used for the treatment of bacterial skin diseases. If impetigo, hair follicle, tinea pedis secondary suppurative infection, eczema secondary infection, and other superficial localized infection.
Lomefloxacin Hydrochloride Eye Gel, Lomefloxacin Hydrochloride Eye Drops: Used for infectious diseases of external eyes caused by sensitive pathogenic bacteria, such as conjunctivitis, keratitis, corneal ulcer, dacryocystitis, postoperative infection, etc.
Lomefloxacin Hydrochloride Ear Drops: Used for otitis media, external otitis and tympanitis caused by sensitive bacteria.
6, Adverse reactions:
Lomefloxacin Hydrochloride Tablets, Lomefloxacin Hydrochloride Capsule, Lomefloxacin Hydrochloride Dispersible Tablets, Lomefloxacin Hydrochloride Granules:
1. Gastrointestinal reactions are common and may be manifested as abdominal discomfort or pain, diarrhea, nausea or vomiting.
2, central nervous system reaction: dizziness, headache, drowsiness or insomnia.
3, allergic reaction: rash, skin itching, occasionally exudative pleomorphic erythema and angioneurotic edema. Among them, photosensitive reaction is more common than other quinolones.
4. In a few patients, the increase of serum aminotransferase and BUN and the decrease of peripheral blood leukocytes were observed, most of which were mild and transient.
7, Occasionally:
(1) epileptic seizure, mental abnormality, irritability, confusion of consciousness, sensation, tremor.
(2) manifestations of interstitial nephritis, such as hematuria, fever and rash.
(3) Crystallized urine, more common in high doses.
(4) joint pain.
Lomefloxacin Hydrochloride Eye Gel: Occasional transient irritation (local burning, etc.).
Lomefloxacin hydrochloride eye drops: local drops can have transient irritation symptoms, do not affect the use.
Lomefloxacin Hydrochloride Ear Drops: Occasionally middle ear pain and itching.
8, Pharmacological effects:
1. This product is an antimicrobial quinolone. It has high antibacterial activity against Enterobacteriaceae bacteria such as Escherichia coli, Shigella, Klebsiella, Proteus, Enterobacteria, etc. Haemophilus influenzae, Neichenia gonorrhoeae and other products also showed high sensitivity; It also has a certain antibacterial effect on Acinetobacter, Pseudomonas aeruginosa, Staphylococcus, Pneumococcus, Hemolytic Streptococcus, etc.
2, this product through the action on the bacterial cell DNA helical enzyme A subunit, inhibit the synthesis and replication of DNA and play A bactericidal effect.
9, Pictures of the product :