Cas 57-85-2 99% Testosterone Propionate Powder Male Hypogonadism

Testosterone Propionate Androgens No Disease Of Testosterone Cryptorchidism Male hypogonadism

1. Product title:Testosterone Propionate

2. Product parameter table:

3. Product Description:The effect is the same as that of testosterone and testosterone, but the action time of intramuscular injection is longer, and it can be injected once every 2 ~ 3 days. Clinical applicable to non - testosterone disease, cryptorchidism, male hypogonadism; Gynecological diseases such as menorrhagia and uterine fibroids; Senile osteoporosis and aplastic anemia. By stimulating the kidney to secrete erythropoietin or directly stimulating the bone marrow. Androgen replacement therapy for primary hypotesticular function; Sexual organ dysplasia.
Large dosage can cause female masculinity, edema, liver damage, jaundice, dizziness and so on. People with allergic reactions should stop taking the medicine immediately. It should not be used in patients with liver and renal insufficiency, prostate cancer and pregnant women. If there is crystal precipitation in injection, it can be heated and dissolved before injection. Delayed pubertal development and dwarfism; All kinds of chronic wasting diseases. In vivo, 5α-dihyrotesterone (5α-dihyrotesterone) is firstly transformed into 5α-dihyrotesterone (5α-dihyrotesterone), which later binds to cell receptors and enters the nucleus where it interacts with chromatin to activate RNA polymerase and promote protein synthesis and cell metabolism. In addition, testosterone propionate stimulates erythropoietin (EPO) production and differentiation of red blood cells. Although this product can be absorbed orally, but the liver will be damaged quickly and ineffective, so the general use of intramuscular injection. After intramuscular injection of testosterone propionate, absorption is slow and its prolonged effect time is 2-4 days. In the blood, 98% of testosterone binds to the sex hormone globulin, and only 2% is free. Half-life is 10-20 minutes. After the inactivation of testosterone in the liver, the metabolites are androsterone, isoandrosterone and cholanolone. They are excreted 90% in the urine in combination with uronic acid and sulfuric acid. About 6% of the unbound form of the product is excreted by bile, a small portion of which can be reabsorbed to form the enterohepatic circulation.

4. Physical and chemical properties of testosterone propionate:

The density of 1.1 + / - 0.1 g/cm3
Boiling point 454.6±45.0 °C at 760 mmHg
The melting point of 118-123 ° C
Molecular formula C22H32O3
The molecular weight of 344.488
Flash point 196.3 + / - 28.8 ° C
Accurate mass 344.235138
PSA 43.37000
LogP 4.90
Appearance white to off-white crystalline powder
Vapor pressure 0.0± 1.1mmHg at 25°C
The refractive index of 1.538
Storage conditions
This product should be sealed in a cool and dry place for storage.

Water solubility ethanol: 10 mg/mL | & lt; 0.1g / 100ml at 24.5 ° C
The molecular structure
V. Molecular property data:

1. Molar refractive index: 97.32

2. Molar volume (m3/mol) : 311.2

3. Equivalent specific volume (90.2K) : 792.3

4, surface tension (dyne/cm) : 42.0

5. Polarizability (10-24cm 3) : 38.58

Computational chemistry
1. Calculation reference value of hydrophobic parameters (XLOGP) : none

2. Number of hydrogen bond donors :0

3. Number of hydrogen bond receptors :3

4. Number of rotatable bonds :3

5. Number of tautomers :5

6. Polar surface area of topological molecules

7. Number of heavy atoms :25

8. Surface charge :0

9. Complexity :621

10. Number of isotopic atoms :0

11. Determine the number of protosteric centers :6

12. Number of uncertain atomic structuring centers :0

13. Determine the number of chemical bond formation centers :0

14. Uncertain number of bond structuring centers :0

15. Number of covalent bond units :1

More and more
1. Properties: white crystal.

2. Density (g/mL,25/4℃) : not determined

3. Relative vapor density (g/mL, air =1) : not determined

Melting point (° C) : 118 ~ 122

5. Boiling point (° C, atmospheric pressure) : not determined

6. Boiling point (° C,5.2kPa) : Undetermined

7. Refractive index: not determined

8. Flash point (° C) : Undetermined

9. Specific Rotation (°) : [α]D25 +83° +90° (C=0.1, in dioxane)

10. Spontaneous ignition point or ignition temperature (° C) : not determined

11. Vapor pressure (kPa,25 ° C) : Undetermined

12. Saturated vapor pressure (kPa,60 ° C) : Undetermined

13. Heat of combustion (kJ /mol) : not determined

14. Critical temperature (° C) : Undetermined

15. Critical pressure (kPa) : not determined

16. The logarithm of the oil-water (octanol/water) partition coefficient: not determined

17. Explosion upper limit (%,V/V) : not determined

18. Lower explosion limit (%,V/V) : not determined

19. Solubility: soluble in ethanol, ether, pyridine and other organic solvents, soluble in vegetable oil, insoluble in water.

5. Matters needing attention:Liver function should be checked regularly in the course of medication, and if damage is found, medication should be stopped in time. If there is crystal precipitation in injection, it can be heated and dissolved before use. Deep intramuscular injection should be given and should not be used for intravenous drip. In the treatment of breast cancer, the drug should be effective within 3 months, if the disease continues to progress, should be stopped immediately. It is generally not used in exchange for other testosterone preparations because of their different duration of action.

6. Pictures of the product: