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Cas 53-43-0 Dehydroepiandrosterone Powder For Hormonal Drugs Contraceptives

Cas 53-43-0 Dehydroepiandrosterone Powder For Hormonal Drugs Contraceptives

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    Dehydroepiandrosterone Powder

    ,

    cas 53-43-0

    ,

    Purity 99% Dehydroepiandrosterone

  • Product Name
    Dehydroepiandrosterone
  • Purity
    99%
  • Appearance 
    White Crystalline Powder
  • Shelf Life
    2 Years
  • CAS No
    53-43-0
  • Storage
    Cool Dry Place
  • Boiling Point
    426.7±45.0 °C At 760 MmHg
  • Melting Point
    146-151ºC
  • Flash Point
    182.1±21.3 °C
  • Density
    1.1±0.1 G/cm3
  • Place of Origin
    India
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
    1kg
  • Price
    To discuss
  • Packaging Details
    1kg-25kg
  • Delivery Time
    2
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability
    200000

Cas 53-43-0 Dehydroepiandrosterone Powder For Hormonal Drugs Contraceptives

Dehydroepiandrosterone The Main Raw Material For Hormonal Drugs And Contraceptives

 

1. Product title:Dehydroepiandrosterone

2. Product parameter table:

Product name Dehydroepiandrosterone appearance White crystalline powder
Use of the product The Main Raw Material For Hormonal Drugs And Contraceptives content 99%
Brand Name Kan Ying Shelf Life 2 Years
place of origin India Storage Cool Dry Place

3. Product Description: Dehydroepiandrosterone is an organic compound with a chemical formula of C19H28O2. It is a white crystalline powder. It is soluble in benzene, ethanol, ether, hardly soluble in chloroform, and petroleum ether. It is used to produce steroid hormone drugs and contraceptives. main ingreadient.

4. Dehydroepiandrosterone biological activity:

Description DHEA is one of the most abundant steroid hormones. DHEA mediates its effects through a variety of signal transduction pathways, and through its specificity through conversion into androgens and estrogen derivatives (for example, androgens, estrogen, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) Sex receptors work.
Related categories
Signaling Pathway >> Others >> Androgen Receptor
Natural Products >> Steroids
Research Field >> Endocrinology
Target
Human Endogenous Metabolite

In vitro studies DHEA is an effective anti-apoptotic factor, which can reverse the apoptosis induced by serum deprivation in prostate cancer cells (DU145 and LNCaP cell lines) and colon cancer cells (Caco2 cell lines). DHEA significantly reduced apoptosis induced by serum deprivation in all three cancer cell types, quantified by APOPercentage assay (apoptosis decreased from 0.587±0.053 to 0.142±0.0016 or 0.059±0.002 after 12 hours of treatment with DHEA or NGF, respectively ; n = 3, P <0.01), and DU145 cells were detected by flow cytometry analysis (FACS). The anti-apoptotic effect of DHEA is dose-dependent, with EC50 at nanomolar concentration (EC50 in DU145 and Caco2 cells: 11.2±3.6nM and 12.4±2.2nM, respectively) [1]. DHEA is the main human sex steroid precursor, which can be directly converted into androgens. As assessed by the thymidine incorporation assay, DHEA (≥1 μM) caused a dose-dependent inhibition of Chub-S7 proliferation. DHEA treatment inhibited the expression of key glucocorticoid regulatory genes H6PDH (≥100nM) and HSD11B1 (≥1μM) in predifferentiated adipocytes in a dose-dependent manner. Consistent with this result, DHEA treatment (≥1μM) resulted in a significant decrease in 11β-HSD1 oxidoreductase activity (≥1μM), and a simultaneous increase in dehydrogenase activity at the highest DHEA dose (25μMDHEA) used in differentiated adipocytes[ 2].
In vivo study Compared with mice fed the control AIN-76A diet, DHEA (0.45% w/w) in the diet of male B6 mice (group of 5 mice) treated for 8 weeks resulted in a significant decrease in body temperature. Similar comparisons show that there are significant differences between control and pair-fed mice. The temperature of the animals fed DHEA was significantly lower than that of the mice fed the control diet 26/29 times; the mice fed the DHEA diet were less affected, and the 8/29 value was significantly lower than that of the mice fed AIN-76A ad libitum. mouse. The temperature of DHEA-fed or DHEA-fed mice was significantly different in the test by 21/29 times. The body weight of the mice fed the control diet was significantly higher than the body weight of the mice fed or fed DHEA. Except for the 9th week (n = 3), the average weekly food intake from the cage (g/day) (n = 7). The food intake of mice fed DHEA was significantly reduced. By design, the pair of mice fed DHEA ate approximately the same amount. Therefore, it seems that DHEA lowers body temperature through food restriction and a separate mechanism [3].
Kinase experiment Chub-S7 cells were incubated in DMEM containing cold DHEA (20nM) and tritiated DHEA (0.2μCi/well) for 48 hours. After incubation, the steroids were extracted with dichloromethane, and separated by thin-layer chromatography using n-hexane/1-hexanol (75:25) as the mobile phase system. The metabolites are identified by migration with an unlabeled reference steroid, which is visualized by exposure to Lieberman-Burchard reagent (ethanol-acetic anhydride-sulfuric acid). A LabLogic AR-200 scanner was used to quantify steroid conversion. The protein concentration was measured using a colorimetric 96-well plate assay and used to normalize the transformation. The activity is expressed as a conversion percentage [2].
Cell experiment Chub-S7 preadipocytes and human primary preadipocytes were seeded into 24-well plates at densities of 1×105 and 2.5×105, respectively. After overnight culture, the medium is supplemented with DHEA, androstendiol or DHEAS (0-100μM). After 24, 48 or 72 hours of incubation, cell proliferation was assessed by incubating with radiolabeled thymidine (0.2 μCi/well) for the last 6 hours. The protein was precipitated with TCA and the cells were scraped in NaOH. The corresponding content of radiolabeled nuclear material in the resulting lysate was analyzed by scintillation counting. The data is expressed as a percentage of the control [2].
Animal experiments Mice[3] fed Purina Lab Chow to mice until the start of the experiment (day 0). Then a group of 5 mice was fed between 0900 and 1000 hours, which contained precipitated AIN-76A diet without additives or DHEA (0.45% w/w). Store the diet at 4°C for no more than six months to maintain optimal activity. Except for mice that were paired with DHEA-treated mice, the mice were given a diet ad libitum. The amount of AIN-76A diet fed to paired-fed mice is determined by the weight of food consumed by mice fed DHEA each day. The body weight (g) was measured at different time points from the beginning of day 1 to the end of day 59. The daily food intake (g/day) was determined by weighing the food consumption of each 5 mice. Calculate the mean±SEM value from week 1 to week 8 (n = 7); there are only 3 days in week 9.

5. Pictures of the product:

Cas 53-43-0 Dehydroepiandrosterone Powder For Hormonal Drugs Contraceptives 0Cas 53-43-0 Dehydroepiandrosterone Powder For Hormonal Drugs Contraceptives 1