Yellow Sulfadiazine Powder

Tannin As An Astringent, It Can Precipitate Proteins And Form Insoluble Complexes With Alkaloids, Glycosides And Heavy M

1. Product title:Sulfadiazine

2. Pictures of the product:

3. Product Description:Sulfadiazine belongs to the effect of sulfanilamide, for the enzyme production gold bacteria, pyogenic streptococcus, streptococcus pneumoniae and e. coli, klebsiella bacteria genera, salmonella, shigella genus enterobacteriaceae bacteria, neisseria gonorrhoeae, meningococcal, h. influenzae antimicrobial effect, in addition to chlamydia trachomatis in vitro, star slave card bacteria, parasites and toxoplasma have antimicrobial activity. This product has the same antibacterial activity as sulfamethoxazole . But in recent years, the resistance of bacteria to this product increased, especially Streptococcus, Neisseria and Enterobacteriaceae bacteria. Sulfonamides are broad-spectrum bacteriostatic agents. This product is similar to p-aminobenzoic acid (PABA) in structure. It can compete with PABA to act on dihydrofolate synthetase in bacteria, thus preventing PABA as raw material to synthesize folic acid needed by bacteria and reducing the amount of metabolically active tetrahydrofolate. The latter is necessary for the synthesis of purines, thymine nucleosides and deoxyribonucleic acid (DNA) by bacteria, thus inhibiting the growth and reproduction of bacteria.

4. Physical and chemical properties of sulfadiazine:

The density of 1.5 + / - 0.1 g/cm3
Boiling point 512.6±52.0 °C at 760 mmHg
Melting point 253 °C (Dec.)(lit.)
Molecular formula C10H10N4O2S
The molecular weight of 250.277
Flash point 263.8 + / - 30.7 ° C
Accurate mass 250.052444
PSA 106.35000
LogP - 0.12 -
Appearance white to slightly yellow crystalline powder
Vapor pressure 0.0±1.3 mmHg at 25°C
The refractive index of 1.679
Storage conditions
Keep sealed from light.

5. Computational chemistry:

 Calculation reference value of hydrophobic parameters (XLOGP) : none

 Number of hydrogen bond donors :2

 Number of hydrogen bond receptors :6

 Number of rotatable bonds :3

 Number of tautomers :2

 Topological molecular polar surface area 106

 Heavy Atoms :17

 Surface charge :0

 Complexity :327

 Number of isotopic atoms :0

Determine the number of protosteric centers :0

Number of uncertain atomic structuring centers :0

Determine the number of chemical bond formation centers :0

Uncertain number of bond structuring centers :0

 Number of covalent bond units :1

More and more
 Properties: white or almost white crystal or powder, odorless, tasteless, gradually dark when light

 Density (g/mL,25/4℃) : indeterminate

 Relative vapor density (g/mL, air =1) : uncertain

 Melting point (° C) : 253 (Dec.)(lit.)

 Boiling point (° C, atmospheric pressure) : not certain

Boiling point (° C, 5.2kPa) : Uncertain

Refractive index: uncertain

 Flash point (° C) : Uncertain

Specific rotation (°) : Uncertain

Spontaneous ignition point or ignition temperature (° C) : uncertain

Vapor pressure (kPa,25 ° C) : Uncertain

 Saturated vapor pressure (kPa,60 ° C) : uncertain

 Heat of combustion (kJ /mol) : uncertain

Critical temperature (° C) : Uncertain

Critical pressure (kPa) : not certain The logarithm of the oil-water (octanol/water) partition coefficient: uncertain

Upper limit of explosion (%,V/V) : Uncertain

Lower limit of explosion (%,V/V) : uncertain

 Solubility: Almost insoluble in water, at 37℃, pH=5.6 water solubility is 13mg/ 100mL, pH=7.5 water solubility is 200mg/ 100mL. Slightly soluble in ethanol or acetone, easily soluble in dilute hydrochloric acid, sodium hydroxide solution or ammonia solution

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