Prednisone Dragon Weight Loss Powder Allergy Suppress The Immune
1. Product title:Prednisone Dragon
2. Pictures of the product:
|Product Name||Prednisone Dragon||Specification||99%|
|Appearance||White powder||Main Effect||Allergy Suppress The Immune|
|Brand Name||Kan Ying||Store-method||Cool Dry Place|
|Shelf Life||2 Years When
3. Product Description:Intermediate acting adrenal cortex JISU class of drugs. It has anti-inflammatory, anti-allergic and immunosuppressive pharmacological effects. It is mainly used for severe bacterial infection and severe allergic diseases, various thrombocytopenic purpura, granulocytopenia, severe skin diseases, immune rejection of organ transplantation, tumor treatment and eye inflammation sensitive to glucocorticoid JISU.
4. Compound-related drugs:category:
Chemicals and Biological Products >> Tumor Treatment Drugs >> Anti-tumor Drugs >> Hormonal Anti-tumor Drugs
Chemicals and biological products >> Drugs that affect immune function >> Immunosuppressants >> Adrenal cortex hormones
Chemicals and biological products >> Metabolism and endocrine system drugs >> Adrenal corticosteroids >> Glucocorticoids 
This product is a white piece. 
Mainly used for allergic and autoimmune inflammatory diseases, collagen diseases, such as rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, nephrotic syndrome, thrombocytopenic purpura, neutropenia, acute lymph Leukemia, various adrenal insufficiency, exfoliative dermatitis, herpes neurodermatitis, eczema, etc. 
For the treatment of allergic and inflammatory diseases, the daily dose for adults is 15-40mg according to the severity of the disease, and 60mg when needed, or 0.5-1mg/kg per day, divided into three times for fever patients, and those with normal body temperature get up every morning Take one meal at a time. After the condition is stable, the dosage should be gradually reduced, and the maintenance amount should be 5-10mg, depending on the condition. 
Glucocorticoids have no obvious adverse reactions in the application of physiological dose replacement therapy. The adverse reactions mostly occur in the application of pharmacological doses, and are closely related to the course of treatment, dosage, usage and route of administration. Common adverse reactions include the following categories:
1. Long-term use can cause the following side effects: iatrogenic Cushing’s syndrome, facial appearance and posture, weight gain, lower extremity edema, purple streaks, tendency to bleeding, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, bone Porosity and fractures (including spinal compression fractures, pathological fractures of long bones), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, growth in children Suppression, glaucoma, cataracts, benign intracranial pressure syndrome, impaired glucose tolerance, and exacerbation of diabetes.
2. Patients may have psychiatric symptoms: euphoria, agitation, delirium, restlessness, disorientation, and can also be manifested as inhibition. Mental symptoms are caused by people who are prone to and suffering from chronic wasting diseases and those who have had mental disorders in the past.
3. Concurrent infection is the main adverse reaction of adrenal cortex hormones. Mainly fungi, tuberculosis, staphylococcus, proteus, Pseudomonas aeruginosa and various herpes viruses.
4. Glucocorticoid withdrawal syndrome. Sometimes patients experience dizziness, fainting tendency, abdominal pain or back pain, low fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, and weakness after stopping the drug. After careful examination, if the adrenal cortex dysfunction and the original disease can be ruled out The resurgence of patients can be considered as a dependency syndrome on glucocorticoids. 
1. People who are allergic to this product and other steroid hormones are prohibited.
2. Patients with the following diseases are generally not suitable for use. Special circumstances should weigh the pros and cons. However, it should be noted that the disease may worsen: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis, fracture, trauma repair period , Corneal ulcers, adrenal hyperfunction, hypertension, diabetes, pregnant women, infections that cannot be controlled by antibacterial drugs such as chickenpox, measles, fungal infections, severe osteoporosis, etc. 
1. Induced infection: Under the action of hormones, the originally controlled infection can be activated, and the most common case is the recurrence of tuberculosis infection. In certain infections, the application of hormones can reduce tissue damage, reduce exudation, and relieve symptoms of infection and poisoning. However, effective antibiotics must be used at the same time, and the changes in the condition must be closely observed. After short-term medication, the dose should be reduced and the drug should be stopped quickly.
2. Interference with diagnosis:
(1) Glucocorticoids can increase blood sugar, blood cholesterol, blood fatty acids, and blood sodium levels, and decrease blood calcium and potassium.
(2) The effects on the peripheral blood picture include a decrease in the number of lymphocytes, eukaryotic cells, and eosinophils and basophils, and an increase in multinucleated white blood cells and platelets. The latter may also decrease.
(3) Long-term high-dose glucocorticoids can make skin test results false negative, such as tuberculin test, histoplasmin test and allergic reaction skin test.
(4) It can also reduce the uptake rate of thyroid I, weaken the response of thyroid stimulating hormone (TSH) to TSH releasing hormone (TRH) stimulation, and make the TRH excitability test result false positive. Interfering with the results of the luteinizing hormone releasing hormone (LHRH) excitation test.
(5) Make the isotope brain and bone imaging weakened or sparse.
3. The following conditions should be used with caution: heart disease or acute heart failure, diabetes, diverticulitis, emotional instability and psychosis, systemic fungal infection, glaucoma, liver damage, herpes simplex of the eye, hyperlipoproteinemia, high blood pressure , Hypothyroidism (the effect of corticosteroids is enhanced at this time), myasthenia gravis, osteoporosis, gastric ulcer, gastritis or esophagitis, renal damage or stones, tuberculosis, etc.
4. Follow-up inspection: For long-term use of glucocorticoids, the following items should be checked regularly:
(1) Blood glucose, urine glucose or glucose tolerance test, especially for people with diabetes or diabetic tendency.
(2) Children should be tested regularly for growth and development.
(3) Eye examination, pay attention to the occurrence of cataract, glaucoma or eye infection.
(4) Serum electrolytes and fecal occult blood.
(5) The examination of hypertension and osteoporosis, especially for the elderly. 
Medication for pregnant and lactating women:
1. Medication during pregnancy: glucocorticoids can pass through the placenta. Animal experiments have confirmed that administration during pregnancy can increase the incidence of embryonic cleft palate, placental insufficiency, spontaneous abortion and intrauterine growth retardation. Human use of pharmacological doses of glucocorticoids can increase the incidence of placental insufficiency, neonatal weight loss or stillbirth.
2. Medications during lactation: Because glucocorticoids can be excreted in milk, they can cause adverse effects on infants, such as growth inhibition and adrenal cortex function inhibition.
Pregnant and breastfeeding women should avoid using it as much as possible after weighing the pros and cons. 
If children use adrenal cortex hormones for a long time, they must be very cautious. 
Glucocorticoids in elderly patients are prone to hypertension and diabetes. Elderly patients, especially women after menopause, are prone to aggravate osteoporosis with glucocorticoids. 
1. Non-steroidal anti-inflammatory analgesics can enhance their ulcer-causing effects.
2. It can enhance the liver toxicity of acetaminophen.
3. Combined use with amphotericin B or carbonic anhydrase inhibitors can aggravate hypokalemia. Long-term combined use with carbonic anhydrase inhibitors is prone to hypocalcemia and osteoporosis.
4. Combined use with protein anabolic hormones can increase the incidence of edema and make acne worse.
5. Long-term combined use with anticholinergic drugs (such as atropine) can increase intraocular pressure.
6. Tricyclic antidepressants can aggravate the mental symptoms caused by them.
7. When combined with hypoglycemic drugs such as insulin, it can increase the blood sugar of diabetic patients, so the dosage of hypoglycemic drugs should be adjusted appropriately.
8. Thyroid hormones can increase the metabolic clearance rate, so when thyroid hormones or antithyroid drugs are used in combination with them, the dosage of the latter should be adjusted appropriately.
9. Combined use with contraceptives or estrogen preparations can enhance its therapeutic effects and adverse reactions.
10. Combined with cardiac glycosides, it can increase the toxicity of digitalis and the occurrence of arrhythmia.
11. Combined use with potassium excretion diuretics can cause severe hypokalemia and weaken the natriuretic and diuretic effects of diuretics due to water and sodium retention.
12. Combined use with ephedrine can enhance its metabolic clearance.
13. Combined use with immunosuppressive agents can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases.
14. It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and curative effect of isoniazid.
15. It can promote the metabolism of mexiletine in the body and reduce the blood concentration.
16. Combined use with salicylate can reduce the concentration of plasma salicylate.
17. Combined with growth hormone, it can inhibit the growth-promoting effect of the latter. 
Can cause adrenal hyperfunction syndrome. 
Pharmacology and Toxicology:
Adrenal cortex hormone drugs. Super-physiological glucocorticoids have a variety of pharmacological effects such as anti-inflammatory, anti-allergic and immune suppression.
1. Anti-inflammatory effects: glucocorticoids reduce and prevent tissue response to inflammation, thereby reducing the performance of inflammation.
2. Immunosuppressive effects: prevent or inhibit cell-mediated immune responses, delayed allergic reactions, reduce the number of T lymphocytes and monocyte eosinophils, reduce the binding ability of immunoglobulins and cell surface receptors, and inhibit interleukins Synthesis and release, thereby reducing the transformation of T cells to lymphoblasts, and reducing the expansion of the primary immune response.
3. Anti-toxic and anti-shock effects: Glucocorticoids can counteract the stimulating response of bacterial endotoxin to the body, reduce cell damage, and play a role in protecting the body. 
This product is easily absorbed by the digestive tract. It exists in an active form and exerts its biological effects without being transformed by the liver. The plasma concentration reaches its peak about 1 to 2 hours after oral administration, and the t1/2 is 2 to 3 hours. In the blood, most of this product is bound to plasma proteins (but the binding rate is lower than that of hydrocortisone), free and bound metabolites are excreted in the urine, some are excreted in their original form, and a small portion can be excreted through breast milk. 
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