The Third Generation Of Cephalosporin Antibiotic Cefoxime Aminothioxime Cephalosporin Sefosol Daliphant Pannin Noprotiol
Product name: cefixime
Product Description:Cefixime is an oral third-generation cephalosporin antibiotic commonly used to treat gonorrhea, tonsillitis, and pharyngitis. The usual dose is 400 milligrams for up to 5-7 days a day. Cefoxime was sold in the United States under the name "Suprax" until 2003, when its patent lapsed and Wyeth, the drug company that owned the patent, pulled it from the shelves. Later, Suprax was re-launched by Lupin Pharmaceuticals, but in oral suspension form. Substitutes are now produced by pharmaceutical companies all over the world, the largest of which is in India.
Chemical formula: C16H15N5O7S2
Molecular weight: 453.452 g/mol
The basic characteristics of:
White to light yellow crystalline powder, tasteless, slightly smelly, easily soluble in methanol, dimethyl sulfone, slightly soluble in acetone, difficult to dissolve in ethanol, almost insoluble in water, ethyl acetate, ethyl ether, hexane.
To adapt to the symptoms
It is suitable for bronchitis, pneumonia, pyelonephritis, cystitis, urethritis, cholecystitis, cholangitis, scarlet fever, otitis media, sinusitis.
This product is the third generation of oral cephalosporin, antibacterial spectrum is wide, to pyogenic streptococcus, pneumococcus, agalactiae streptococcus, gonorrhea coccus, influenzae, Moracatae and Escherichia coli, pneumoniae and other Enterobacteriaceae bacteria has a good antibacterial activity. The product had no effect on group D streptococcus, enterococcus, listeria, most staphylococcus, enterobacteria, Pseudomonas aeruginosa and other pseudomonas. Cefoxime is highly stable to β-lactamase and has a high affinity with penicillin-binding proteins 3, 1A and 1B, which hinders bacterial cell wall synthesis and causes rapid bacterial dissolution and death.
Precautions1. The safety and effectiveness of cefixime for pregnant women, breastfeeding women, and children under 6 months of age have not been established. Pregnant women need to weigh the pros and cons before use. The U.S. Food and Drug Administration (FDA) has classified the pregnancy safety of cefixime as Class B. Breastfeeding women should stop breastfeeding when using cefixime.
2. The following patients should be used with caution: ①Patients with a history of penicillin allergy; ②Patients with allergies in themselves and their immediate family members; ③Patients with renal insufficiency; ④Patients with difficulty in oral administration or non-oral intake of nutrition, systemic cachexia Patients with status (because vitamin K may appear); ⑤Patients with pseudomembranous enteritis.
3. The course of treatment of Streptococcus pyogenes infection requires at least 10 days.
4. When the dosage used is the same, the plasma concentration of the oral suspension is 25%-50% higher than that of the oral tablet. Patients with otitis media should be treated with suspensions.
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