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C47H75NO17 Nystatin Suspension Cell Culture Tested Powder Cas 1400-61-9

C47H75NO17 Nystatin Suspension Cell Culture Tested Powder Cas 1400-61-9

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    C47H75NO17 Nystatin Suspension Cell Culture Tested

    ,

    Nystatin Suspension Cell Culture Tested Powder

    ,

    cas 1400-61-9

  • Product Name
    Nystatin Suspension Cell Culture Tested
  • Molecular Formula
    C47H75NO17
  • Quality Standard
    USP26
  • Purity
    99%
  • CAS
    1400-61-9
  • WhatsApp
    +86 17520158967
  • Shelf Life
    2 Years
  • Storage
    Cool Dry Place
  • Place of Origin
    India
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
    1KG
  • Price
    To discuss
  • Packaging Details
    1KG/25KG
  • Delivery Time
    2
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability
    2000000

C47H75NO17 Nystatin Suspension Cell Culture Tested Powder Cas 1400-61-9

Fungal infection of digestive tract bacteriostatic Oral Hypoglycemic Agents

 

1, Product title:nystatin suspension cell culture tested

 

2, Product parameter table: 

 

Product name nystatin suspension cell culture tested appearance Yellow or yellowish brown powder
Use of the product Digestive tract candida enteritis, oral candida infection content 99%
Molecular formula C47H75NO17 Shelf Life 2 Years
CAS 1400-61-9 Storage Cool Dry Place

 

 

3, Product Description:

 

It is a yellow or yellowish brown powder with special odor, moisture inducing bacterial spectrum and antibacterial mechanism similar to amphotericin B. It is mainly used for Candida albicans infection of skin mucosa, oral cavity and Yidao

 

4, Use of the product :

 

It is mainly used for internal administration to treat fungal infection of digestive tract or external use for superficial fungal infection of skin.

 

Such as bovine fungal gastritis, chicken and Turkey bursal mycosis, on Aspergillus, Mucor caused mastitis, milk duct perfusion is also effective. Spray inhalation is also effective for chicken pneumonia caused by Aspergillus fumigatus.

 

 

5Biological activity of nystatin:

Nystatin is a polyene antifungal antibiotic that is effective against yeast and mycoplasma.
Related categories
Signaling pathway >; > Anti-infection & gt; > fungi
Research Fields > > infection
In vitro studies of nystatin resulted in a significant decrease in buccal epithelial cell adhesion in all six Candida species [1]. Nystatin is an antibiotic that increases plasma membrane permeability to small univalent ions, including chloride ions. Nystatin increases apical chloride permeability, so that trans-epithelial chloride transport is limited by transport across the basolateral membrane of tracheal epithelial cells, which mainly reflects the activity of cotransporters. Nystatin (400 units/mL) increased the base level of trans-epithelial 36CL flux by approximately 1.5 times and eliminated the UTP stimulation of that flux. Nystatin treatment also eliminated saturable basolateral [3H] bumetanil binding UTP stimulation, a measure of functional Na-K-CL cotransporters in these cells; The stimulation of binding by isoprene was only slightly inhibited by nystatin treatment [2]. Nystatin significantly enhances endostatin uptake by endothelial cells through endostatin internalization, which is mainly converted to clathrin mediated pathway. Nystin-enhanced endostatin internalization also increases its inhibitory effect on endothelial tube formation and migration [3].
In vivo studies, the combination of nystatin and endostatin selectively enhanced endostatin uptake and biological distribution in tumor blood vessels and tumor tissues, but failed to enhance endostatin uptake in normal tissues of tumor-bearing mice, ultimately leading to increased antiangiogenesis and anti-tumor efficacy of endostatin in vivo [3]. Lipogenic nystatin, at doses as low as 2 mg/kg bw/day, protected neutropenia mice in a statistically significant manner against Aspergillus induced death at a 50-day time point compared with no treatment, normal saline, or salt-free treatment. Empty liposome group [4].
reference
[1]. Ellepola AN, et al. Adhesion of oral Candida species to human buccal epithelial cells following brief exposure to nystatin. Oral Microbiol Immunol. 1999 Dec; 14 (6) : 358-63.

[2]. Haas M, et al. Na-K-Cl cotransport in nystatin-treated tracheal cells: regulation by isoproterenol, apical UTP, and [Cl]i. Am J Physiol. 1994 May; 266(5 Pt 1):C1440-52.

[3]. Chen Y, et al. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun 9; 117 (23) : 6392-403

[4]. Wallace TL, et al. Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice. Antimicrob Agents Chemother. 1997 Oct; 41 (10) : 2238-43

 

6. Pictures of the product:

C47H75NO17 Nystatin Suspension Cell Culture Tested Powder Cas 1400-61-9 0C47H75NO17 Nystatin Suspension Cell Culture Tested Powder Cas 1400-61-9 1