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CAS 50-02-2 Dexamethasone Powder API Antibiotic Powder

CAS 50-02-2 Dexamethasone Powder API Antibiotic Powder

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    CAS 50-02-2


    Dexamethasone Powder


    API Antibiotic Powder

  • Product Name
  • Brand Name
    Kan Ying
  • Purity
  • Place Of Origin
  • Storage
    Cool Dry Place
  • CAS No
  • Color
    White Powder
  • Boiling Point
    568.2±50.0 °C At 760 MmHg
  • Melting Point
  • Point Of Flammability
    297.5±30.1 °C
  • Place of Origin
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
  • Price
    To discuss
  • Packaging Details
  • Delivery Time
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability

CAS 50-02-2 Dexamethasone Powder API Antibiotic Powder

dexamethasone The anti-inflammatory Antibiotic API Antiallergic drug


1,  Product title:   Dexamethasone


2,  Product Description:


Like other glucocorticoids, dexamethasone has anti-inflammatory, anti-endotoxin, immunosuppressive, anti-shock and enhancing stress response and other pharmacological effects, so it is widely used in various departments to treat a variety of diseases, such as autoimmune diseases, allergies, inflammation, asthma, dermatology and ophthalmic diseases. Dexamethasone sodium phosphate injection is indispensable first-aid medicine, rescuing critically ill patients in recent years, clinical application of dexamethasone sodium phosphate treatment and prevention of drug allergy caused by all kinds of Chinese and western medicine and treatment of viral cold, such as a fever caused by the disease, make clinical dose dexamethasone increases year by year, so far our country has become the world's largest market of dexamethasone.



3,  Product parameter table:



Product Name Dexamethasone Specification 99%
Appearance White or light white power Main Effect The Anti-Inflammatory
Brand Name Kan Ying Store-method Cool Dry Place
Shelf Life 2 Years When
Properly Stored
From India


4,  In vitro studies:

Dexamethasone regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-κB, leading to activation and suppression of key genes involved in the inflammatory response [1]. Dexamethasone effectively inhibited the release of granulocyte-macrophage colony stimulating factor (GM-CSF) from A549 cells with an EC50 of 2.2 nM. Dexamethasone (EC50 = 36nM) induced β2 receptor transcription was found to be associated with glucocorticoid receptor (GR) DNA binding and occurred at concentrations 10-100 times higher than GM-CSF release inhibition. Dexamethasone (IC50 = 0.5 nM) inhibited 3×κB (NF-κB, IκBα and I-κBβ), which was associated with the inhibition of GM-CSF release.


5,  indications:


Iprednisolone is mainly used for allergic and autoimmune inflammatory diseases. Such as connective tissue disease, severe bronchial asthma, dermatitis and other allergic diseases, ulcerative colitis, acute leukemia, malignant lymphoma and so on. In addition, this drug is also used for the diagnosis of certain adrenal cortical diseases - dexamethasone inhibition test. The product can also be used to prevent neonatal respiratory distress syndrome, reduce intracranial hypertension and Cushing syndrome diagnosis and differential diagnosis of etiology. Because of its weak sodium REDOX effect, it is generally not used as a replacement therapy for adrenocortical hypofunction. Dexamethasone acetate and Dexamethasone sodium phosphate can also be used for intramuscular injection or injection into the joint cavity, soft tissue and other injured sites.


6,  The stability of:

The chemical structure of dexamethasone is that fluorine atom is introduced into the B ring at 9α site of prednisolone and methyl atom is introduced into the D ring at 16α site of prednisolone. Both 9α-fluoride and 16α-methyl significantly enhanced its anti-inflammatory activity, while 16α-methyl significantly reduced the water and sodium retention of dexamethasone. The clinical bioequivalent dose ratio of dexamethasone to prednisolone was 0.75:5, the biological half-life was 36-54 hours, and it was classified as a long-acting glucocorticoid.


7,  Pictures of the product:


CAS 50-02-2 Dexamethasone Powder API Antibiotic Powder 0CAS 50-02-2 Dexamethasone Powder API Antibiotic Powder 1