Zhejiang Kanying Import & Export Co. Ltd 86--17169758851 kanyingexport@gmail.com
Sildenafil Powder Quality Viagra Treatment Of Penile Erectile Dysfunction

Sildenafil Powder Quality Viagra Treatment Of Penile Erectile Dysfunction

  • High Light

    Levodopa Powder C9H11NO4

    ,

    C9H11NO4 Weight Loss Sibutramine

    ,

    Purity 99 Levodopa Powder

  • Product Name
    Sildenafil
  • Brand Name
    Kan Ying
  • Storage
    Cool Dry Place
  • Purity
    99%
  • Shelf Life
    2 Years
  • Main Effect
    Penile Erection Disorder
  • Place Of Origin
    India
  • Boiling Point
    672.4ºC At 760 MmHg
  • Place of Origin
    India
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
    1kg
  • Price
    To discuss
  • Packaging Details
    1kg-25kg
  • Delivery Time
    2
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability
    200000

Sildenafil Powder Quality Viagra Treatment Of Penile Erectile Dysfunction

Sildenafil Powder Quality Viagra Treatment Of Penile Erectile Dysfunction

 

1. Product title: Sildenafil

 

 

2. Product parameter table:

 

Product Name

Sildenafil​

Specification 99%
Appearance White or light white power Main Effect Penile erection disorder
Brand Name Kan Ying Store-method Cool Dry Place
Shelf Life 2 Years When
Properly Stored
From India

 

3. Sildenafil​ Description:

 

Sildenafil is a drug to improve erectile dysfunction. Generally speaking, there are many reasons for erectile dysfunction. This drug has a very good effect on erectile dysfunction caused by cavernous congestion dysfunction, but the effect may not be particularly good for other reasons. The urological surgery that can head for normal hospital had better be checked further, choose medicaments again after making clear specific reason.

 

4.  properties:

 

Sildenafil citrate "also called Viagra Taiwan called wei steel, Chinese referred to as" Viagra "Taiwan wei steel prescription drugs, indications are limited to patients with male erectile dysfunction, please be careful to buy! Viagra is an English transliteration of Viagra. Originally by Pfizer (Pfizer) pharmaceutical company development and production of a treatment of angina pectoris drugs. The result that discovers its treats angina pectoris in clinical trial is general, and have special effect however to treating impotence, this one accidental discovery, make manufacturer flat declare with the medicaments that treats impotence. It was officially approved by the Food and Drug Administration (FDA) for the treatment of impotence on March 27, 1997.
5. pharmacokinetics

Oral absorption is rapid and the absolute bioavailability is about 40%. Its pharmacokinetic parameters are proportional to dose within the recommended dose range. Elimination is dominated by liver metabolism (cytochrome P450 isoenzyme 3A4 pathway), producing an active metabolite whose properties are similar to sildenafil. The combination of potent inhibitors of cytochrome P450 isoenzyme 3A4 (CYP4503A4) (e.g., erythromycin, ketoconazole, itraconazole) and nonspecific inhibitors of cytochrome P450 (CYP450), such as cimetidine and sildenafil, may cause elevated plasma levels of sildenafil (see "Usage and Dosage"). The elimination half-life of sildenafil and its metabolites is about 4 hours.

 

After a single dose of sildenafil 100mg, the average plasma concentration of healthy male volunteers was shown in figure 2:

 

Absorption and distribution: This product is quickly absorbed. Peak plasma concentration (Cmax) was achieved after 30 to 120 minutes (median 60 minutes) of oral administration on an empty stomach. When taken with a high-fat diet, absorption rate decreased, peak time (Tmax) delayed by an average of 60 minutes, and Cmax decreased by an average of 29%. The mean steady-state volume of distribution (Vss) of sildenafil was 105 l, indicating its distribution in tissues. About 96% of sildenafil and its main circulating metabolite (n-demethylated) are bound to plasma proteins. The protein binding rate was independent of the total drug concentration.

 

According to the semen examination results of healthy volunteers after 90 minutes of medication, it can be deduced that the amount of cilanafil in the semen after medication is less than 0.001% of the dose.

 

Metabolism and excretion: Sildenafil is cleared primarily by the liver microsomal enzymes cytochrome P4503A4 (primary pathway) and cytochrome P4502C9 (secondary pathway). The main circulating metabolite is the n-demethylate of sildenafil, which is further metabolized. N-demethylated metabolites have PDE selectivity similar to that of sildenafil, with approximately 50% of the activity on PDE5 in vitro. The plasma concentration of this metabolite is approximately 40% of that of sildenafil, so approximately 20% of sildenafil's pharmacological action is due to its metabolite.

 

After oral or intravenous administration, sildenafil is excreted mainly as metabolites from the stool (about 80% of the oral dose) and a small amount from the urine (about 13% of the oral dose). Pharmacokinetic parameters obtained from population-based pharmacokinetic studies were similar to those obtained from healthy volunteers.

Sildenafil Powder Quality Viagra Treatment Of Penile Erectile Dysfunction 0

Pharmacokinetics in special populations

 

Older adults: The clearance rate of sildenafil was reduced in healthy older volunteers (≥65 years old), and the area under the drug time curve (AUC) of sildenafil and its active N-demethylation metabolites was approximately 84% and 107% higher than that of young healthy volunteers (18-45 years old), respectively. The AUC of free (not bound to plasma protein) sildenafil and its active N-demethylated metabolites correspondingly increased by 45% and 57%, respectively, taking into account the effect of age differences on plasma protein binding.

 

Renal insufficiency: in volunteers with mild (creatinine clearance =50 to 80ml/min) and moderate (creatinine clearance =30 to 49ml/min) renal impairment, the pharmacokinetics of a single dose of sildenafil 50mg did not change. Volunteers with severe renal impairment (creatinine clearance ≤30ml/min) had reduced clearance of sildenafil and almost double the area under the curve (AUC) and Cmax at treatment time compared with the same age group without renal impairment.

 

In addition, the AUC and Cmax of sildenafil n-demethylation metabolites were significantly higher in subjects with severe renal impairment, by 200% and 79%, respectively, compared with subjects with normal renal function.

 

Liver dysfunction: Sildenafil clearance was reduced in volunteers with cirrhosis (Child-Pugh grade A and B), and AUC and Cmax were 84% and 47% higher, respectively, than in the same age group without liver damage. Sildenafil pharmacokinetics in patients with severe liver impairment (Child-Pugh grade C) have not been studied.

 

Thus, increased plasma sildenafil levels are associated with age 65 and older, liver function impairment, and severe renal impairment. The appropriate starting dose for these patients is 25mg (see [usage and dosage]).

 
5. Pictures of the product:
 
Sildenafil Powder Quality Viagra Treatment Of Penile Erectile Dysfunction 1