Alpha adrenergic receptor blockers Avanafil Powder Prevent skin necrosis
1, Product title:Phentolamine Mesilate
2, Product Description:
Phenolamine mesylate, commonly used dosage forms are tablets, capsules, injections, etc. Alpha adrenergic receptor blocker. For the treatment of erectile dysfunction. It is also used for the diagnosis of pheochromocytoma and the treatment of the onset of hypertension caused by it, including hypertension during surgical resection. It can also be used to assist in the diagnosis of pheochromocytoma according to the reaction of blood pressure. Treatment of left ventricular failure. Treatment of extravasation of norepinephrine by intravenous administration to prevent skin necrosis.
3. Physical and chemical properties of phentolamine mesylate:
Density of |
551ºC at 760 mmHg |
---|---|
Melting point |
180-182 °C(lit.) |
Molecular formula |
C18H23N3O4S |
Molecular weight |
377.458 |
Flash point |
287ºC |
Precise quality |
377.140930 |
PSA | 110.61000 |
LogP | 3.18960 |
Appearance |
White to light yellow powder, odorless |
Storage conditions |
Product should be sealed dry storage. |
Stability of | Aq. Solutions Cannot be Stored |
Water solubility |
50 MG/ML |
Computational chemistry |
1. Calculation reference value of hydrophobic parameters (XLOGP) : none
2. Number of hydrogen bond donors :3
3. Number of hydrogen bond receptors :6
4. Number of rotatable bonds :4
5. Number of tautomers :3
6. Topological molecular polar surface area 111
7. Number of heavy atoms :26
8. Surface charge :0
9. Complexity :456
10. Number of isotopic atoms :0
11. Determine the number of protosteric centers :0
12. Number of uncertain atomic structuring centers :0
13. Determine the number of chemical bond formation centers :0
14. Uncertain number of bond structuring centers :0
15. Number of covalent bond units :2 |
|
3,indications:
Phenolamine mesylate tablets/phenolamine mesylate capsules: for the treatment of male erectile dysfunction.
Phentolamine mesylate injection/Phentolamine mesylate for injection: for the treatment and preoperative preparation of pheochromocytoma, for the diagnosis of pheochromocytoma (the phentolamine test), for the prevention and treatment of skin necrosis due to intravenous noradrenaline extravasation, and for the relief of cardiac load in heart failure.
4,Pictures of the product: