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Testosterone Propionate Androgen Drug CAS57-85-2 Spot Raw Material Sexual Enhancement Powder

Testosterone Propionate Androgen Drug CAS57-85-2 Spot Raw Material Sexual Enhancement Powder

  • Product Name
    Testosterone Propionate
  • Color
    White Powder
  • Shelf Life
    2 Years
  • Brand Name
    Kan Ying
  • CAS No
    57-85-2
  • The Molecular Weight
    344.488
  • Molecular Formula
    C22H32O3
  • Flash Point
    196.3±28.8 °C
  • Melting Point
    118-123 °C
  • The Boiling Point
    454.6±45.0 °C At 760 MmHg
  • Place of Origin
    India
  • Brand Name
    Kan Ying
  • Minimum Order Quantity
    1kg
  • Price
    To discuss
  • Packaging Details
    1kg-25kg
  • Delivery Time
    2
  • Payment Terms
    L/C, D/A, D/P, T/T, Western Union, MoneyGram,Dollars
  • Supply Ability
    200000

Testosterone Propionate Androgen Drug CAS57-85-2 Spot Raw Material Sexual Enhancement Powder

1.  Product title:  Testosterone Propionate

 

2. Testosterone Propionate Product Description:

 

Testosterone propionate is a kind of organic matter, chemical formula is C22H32O3, androgen drugs, clinical suitable for no testosterone, cryptorchidism, male hypogonadism; Gynecological diseases such as menorrhagia, uterine fibroids; Senile osteoporosis and aplastic anemia

 

3. English Nicknames:
Testosterone propionate [USAN:JAN]; 17beta-(Propionyloxy)androst-4-en-3-one; 17beta-Hydroxy-4-androsten-3-one 17-propionate; 17beta-Hydroxyandrost-4-en-3-one propionate; 17beta-Hydroxyandrost-4-en-3-one-17beta-propionate; AI3-26378; Agovirin; Androlon; Andronate; Androst-4-en-3-one, 17beta-hydroxy-, propionate; Androsteston; Androtest P; Androteston; Andrusol-P; Aquaviron; Bio-testiculina; CCRIS 575; Enarmon; Enarmon-oil; Homandren; Hormoteston; Masenate; NSC 9166; Nasdol; Okasa-Mascul; Orchiol; Orchistin; Oreton; Oreton propionate; Pantestin; Primotestone; Propiokan; Recthormone testosterone; Solvotest; Sterandryl; Synandrol; Synerone; TP; TP (VAN); Telipex; Testaform; Testex; Testodet; Testodrin; Testogen; Testolets; Testonique; Testormol; Testosid; Testosterone-17-beta-propionate; Testosterone-17beta propionate; Testosterone-17beta-propionate; Testosteroni propionas; Testoxyl; Testrex; Tostrin; Uniteston; Vulvan; delta(sup 4)-Androstene-17-beta-propionate-3-one; neo-Hombreol; Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17beta)-; DEA No. 4000; Testosterone propionate [Androgenic (anabolic) steroids]; 3-oxoandrost-4-en-17-yl propanoate; (8xi,9xi,14xi,17beta)-3-oxoandrost-4-en-17-yl propanoate
Category: androgen drugs
The CAS number: 57-85-2
EINECS no. : 200-351-1
Molecular formula: C22H32O3
Molecular weight: 344.4877
4. Dosage and usage:
Intramuscular injection: usually 25mg once, 2-3 times a week. Androgen deficiency: intramuscular injection 10 ~ 50mg once, 2 ~ 3 times a week. Menorrhagia or uterine fibroids: intramuscular injection of 25 ~ 50mg, twice a week. Functional uterine bleeding, combined with progestin: intramuscular injection of 25 ~ 50mg, once every other day, a total of 3 ~ 4 times. Aplastic anemia: 100mg intramuscular injection once daily or every other day for more than 6 months. Senile osteoporosis: intramuscular injection of 25mg 2 ~ 3 times a week for 3 ~ 6 months.
Female breast cancer and breast cancer bone metastasis: intramuscular injection of 50 ~ 100mg, once every other day, 2 ~ 3 months. Large doses can cause female masculinity, edema, liver damage, jaundice, dizziness and so on. Those who have allergic reaction should stop taking medicine immediately. Liver, renal insufficiency, prostate cancer patients and pregnant women should not use. If there is crystallization precipitation of injection, it can be injected after heating and dissolving. Pregnant and breastfeeding women, prostate cancer patients contraindicated; The liver function should be checked regularly in the process of medication, and the drug should be reduced or stopped if there is liver damage. The dosage should be reduced in preadolescent children, and bone age should be measured once every 6 months. Injection: 10mg (1ml), 25mg (1ml), 50mg (1ml) each.
5. Function:
The effect is the same as that of testosterone and methyltestosterone, but the duration of intramuscular injection is longer, and it can be injected once every 2-3 days. Clinical for no testosterone, cryptorchidism, male hypogonadism; Gynecological diseases such as menorrhagia, uterine fibroids; Senile osteoporosis and aplastic anemia. Action by stimulating the kidneys to secrete erythropoietin, or by directly stimulating the bone marrow. Androgen replacement therapy for primary hypoorchiasis; Sexual organs are stunted.
Large doses can cause female masculinity, edema, liver damage, jaundice, dizziness and so on. Those who have allergic reaction should stop taking medicine immediately. Contraindicated in patients with liver and renal insufficiency, prostate cancer and pregnant women. If there is crystallization precipitation of injection, it can be injected after heating and dissolving. Puberty delay and dwarfism; Various chronic wasting diseases, etc.
6. Function characteristics:
The product is transformed into 5α dihydrotestosterone (5α-dihyrotesterone) in vivo, and then binds to cell receptor, enters the nucleus, interacts with chromatin, activates RNA polymerase, promotes protein synthesis and cell metabolism. In addition, testosterone propionate stimulates erythropoietin production and differentiation. Although this product can be absorbed orally, it will be destroyed quickly and invalid in the liver, so intramuscular injection is generally used. After intramuscular injection of testosterone propionate, absorption is slow, with a duration of 2 to 4 days. In blood, 98% of testosterone is bound to sex hormone globulin and only 2% is free form. The half-life is 10-20 minutes. After the inactivation of testosterone in the liver, the metabolites are androsterone isoandrosterone and procholanolone. 90% of them are excreted in urine in combination with uronic and sulfuric acids. About 6% of the unbound form of the product is excreted by bile, a small portion of which can still be reabsorbed to form the enterohepatic circulation.
7. Adverse reactions:
The 17-α -alkyl substituted testosterone is toxic to the liver and can cause jaundice. Long-term use in female patients may cause acne, hirsutism, coarse voice, altered libido and other masculine manifestations. The drug should be discontinued immediately when liver dysfunction and masculinity in women are detected. Large doses can cause female masculinity, edema, liver damage, jaundice, dizziness and so on.
Those who have allergic reaction should stop taking medicine immediately. Liver, renal insufficiency, prostate cancer patients and pregnant women should not use. If there is crystallization precipitation of injection, it can be injected after heating and dissolving. Pregnant and breastfeeding women, prostate cancer patients contraindicated; The liver function should be checked regularly in the process of medication, and the drug should be reduced or stopped if there is liver damage. The dosage should be reduced in preadolescent children, and bone age should be measured once every 6 months.
8. Drug use:
Promote the formation, development and maturity of male sex organs, and resist estrogen, inhibit endometrial growth and ovarian pituitary function. Promote protein synthesis metabolism, stimulate bone marrow hematopoietic function, stimulate the generation of blood cells. Clinical use for male hypogonadism, no testosterone and cryptorchidism; Gynecological diseases, such as menorrhagia, uterine fibroids, endometriosis, osteoporosis and pediatric aplastic anemia.
Usage and dose: 5mg per tablet, 1-2 tablets per time, twice a day, or sublingual, 2 times a day, one tablet per time. Androgen deficiency: oral 6-20 tablets per day, maintenance 4-12 tablets per day. Menorrhagia or uterine fibroids: sublingual take 1-2 tablets twice a day for 3-6 months. Pediatric aplastic anemia: 1-2mg per kilogram of body weight per day, once or in 2 times.
Side effects and precautions: long-term use of more than 60 tablets per month in female patients can cause acne, hairy, coarse voice, sexual desire changes, etc. Use with caution in patients with liver, kidney and heart dysfunction. Prostate cancer patients contraindicated, pregnant women and lactation contraindicated.
9. Identify:
Take about 5mg of this product, put it into a small test tube, add 0.2ml methanol to dissolve, add about 3mg of sodium nitroferricyanide fine powder, about 50mg of sodium carbonate and about 50mg of ammonium acetate, shake well, stand for 10-30 minutes, it should be blue purple. Take about 0.5mg of this product, put it into a small test tube, add about 1mg of isoniazid and 1ml methanol to dissolve, then add 1 drop of dilute hydrochloric acid, which shows yellow color. The infrared absorption spectrum of the product should be consistent with that of the control spectrum (spectrum set 434). Chromatographic conditions and system applicability test: octadecylsilane bonded silica gel was used as filler; Methanol-water (65:35) was the mobile phase; The detection wavelength was 254nm.
The number of theoretical plates calculated according to progesterone peak should not be less than 1000, and the separation degree of progesterone peak and internal standard material peak should meet the requirements. The preparation of internal standard solution was about 25mg diethylstilbestrol, weighed accurately, placed in 25ml measuring bottle, dissolved in methanol and diluted to scale, shaken well, and obtained. For determination, take about 25mg of this product, weigh it accurately, place it in 25ml measuring bottle, dissolve it in methanol and dilute it to scale, shake well; 5ml of the solution and 5ml of the internal standard solution were carefully measured, placed in a 25ml flask, diluted to scale with methanol, shaken well, 5μl was injected into the liquid chromatograph, and the chromatogram was recorded. Another appropriate amount of progesterone reference substance was taken and determined by the same method. According to the internal standard method to calculate the peak area, get.
10. Measurement:
Take about 25mg of this product, weigh it accurately, put it in a 25ml measuring bottle, dissolve it in methanol and dilute it to scale, shake well; 5ml of the solution and 5ml of the internal standard solution were carefully measured, placed in a 25ml flask, diluted to scale with methanol, shaken well, 5μl was injected into the liquid chromatograph, and the chromatogram was recorded. Another appropriate amount of progesterone reference substance was taken and determined by the same method. According to the internal standard method to calculate the peak area, get.
The infrared absorption spectrum of the product should be consistent with that of the control spectrum (spectrum set 434). Take about 5mg of this product, put it into a small test tube, add 0.2ml methanol to dissolve, add about 3mg of sodium nitroferricyanide fine powder, about 50mg of sodium carbonate and about 50mg of ammonium acetate, shake well, stand for 10-30 minutes, it should be blue purple. Take about 0.5mg of this product, put it into a small test tube, add about 1mg of isoniazid and 1ml methanol to dissolve, then add 1 drop of dilute hydrochloric acid, which shows yellow color. Chromatographic conditions and system applicability test: octadecylsilane bonded silica gel was used as filler; Methanol-water (65:35) was the mobile phase; The detection wavelength was 254nm.
The number of theoretical plates calculated according to progesterone peak should not be less than 1000, and the separation degree of progesterone peak and internal standard material peak should meet the requirements. The preparation of internal standard solution was about 25mg diethylstilbestrol, weighed accurately, placed in 25ml measuring bottle, dissolved in methanol and diluted to scale, shaken well, and obtained.
Method name: Testosterone propionate - testosterone propionate - high performance liquid chromatography
Scope of application: This method uses high performance liquid chromatography to determine the content of testosterone propionate in the bulk drug.
This method is suitable for testosterone propionate API.
Method Principle: After quantitative dilution with methanol and adding internal standard, the sample was entered into HPLC for chromatographic separation. The peak area of testosterone propionate was detected at 241nm with ultraviolet absorption detector, and its content was calculated.
Reagent: methanol
Equipment: 1. Equipment
1.1 High performance liquid chromatograph
1.2 the chromatographic column
Octadecylsilane bonded silica gel as filler, the theoretical number of plates calculated according to the peak of testosterone propionate should not be less than 1000.
1.3 Ultraviolet absorption detector
2. Chromatographic conditions
2.1 Mobile phase: methanol water =80 20
2.2 Detection wavelength: 241nm
2.3 Column temperature: room temperature
Sample preparation: 1. Preparation of internal standard solution
Nolone phenylpropionate was precisely weighed and the solution containing 1.6mg per 1mL was prepared with methanol, which was the internal standard solution.
2. Preparation of reference solution
Precisely weigh testosterone propionic acid reference substance about 25mg, put it in a 25mL measuring bottle, dissolve it in methanol and dilute it to the scale, shake it well. Precisely measure the solution and the internal standard solution 5mL each, put it in a 25mL measuring bottle, dilute it to the scale with methanol, shake it well, then the reference substance solution is obtained.
3. Preparation of test solution
The sample was accurately weighed with about 25mg, placed in a 25mL measuring bottle, dissolved in methanol and diluted to the scale, then shaken well. The solution and the internal standard solution were precisely measured with 5mL each, placed in a 25mL measuring bottle, diluted to the scale with methanol, and shaken well, which was the test solution.
Note: "Precise weighing" means that the weight taken should be accurate to one thousandth of the weight taken. "Precision measurement" means that the accuracy of volume measurement shall conform to the accuracy requirements of the volume pipette specified in the national standard.
Operation steps: 5mL of the control solution and 5mL of the test solution were accurately absorbed and injected into the HPLC. The peak area of testosterone propionate (C22H32O3) was determined by uv absorption detector at the wavelength of 240nm, and its content was calculated.
References: Pharmacopoeia of the People's Republic of China, National Pharmacopoeia Committee, Chemical Industry Press, 2005, 1, p.81.
11. Check:
Take appropriate amount of the product, weigh accurately, dissolve and dilute in methanol to make a solution containing about 1mg per 1ml, as the test solution, take 1ml of precision, put in a 50ml measuring bottle, add methanol and dilute to scale, shake well, as the control solution. According to the chromatographic conditions under the content determination item, inject 10μ L of the reference solution into the liquid chromatograph, adjust the detection sensitivity, and make the peak height of the principal component reach 50% of the full range of the recorder. Then 10μ L of the test solution and 10μ L of the control solution were injected into the liquid chromatograph, and 1.5 times of the retention time of the chromatogram to the principal component peak was recorded.
No more than one impurity peak should be found in the chromatogram of the test product solution. The peak area shall not be larger than 3/4 of the main peak area of the control solution. The product shall be dried at 105℃ to constant weight, and the weight loss shall not exceed 0.5% (Appendix ⅷ L).
12. Precautions:
Regular examination of liver function should be done in the process of medication, if damage should be stopped in time. If there is crystallization precipitation of injection, it can be used after heating and dissolving. Deep intramuscular injection should be used, not intravenous infusion. When used for the treatment of breast cancer, it should be effective within 3 months. If the disease is still progressing, it should be stopped immediately. It is generally not exchanged with other testosterone preparations because of their different duration of action.
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