Sibutramine Weight Loss And Fat Loss Powder CAS106650-56-0

Sibutramine Weight Loss And Fat Loss Powder CAS106650-56-0

[ Product name: flibanserin ]

Diet pills. Obesity treatment, including weight loss and maintenance of weight loss, should be combined with a low-calorie diet and exercise. It is recommended for the treatment of obese patients with bmi ≥30kg/m2 or ≥27kg/m2(with other risk factors such as hypertension, diabetes, dyslipidemia, etc.).

[ Product parameter table ]

English Name:	Sibutramine
English alias:	1-[1-(4-Chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine
CAS no. :	106650-56-0
Molecular formula:	C17H26ClN
Molecular weight:	279.85
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Formula:

Sibutramine (106650-56-0) production method:
1, 3-dibromopropane was slowly dropped into the mixture of p-chlorophenonitrile, KOH and acetonitrile at 25℃. After dropping, continue stirring for 1h, add distilled water, and then extract with ethyl acetate. The extract was washed with water and saturated salt and dried. After filtration, decompression concentration and distillation, the fraction of 160℃/2.13kPa was collected to obtain compound (ⅰ) with yield of 73% ~ 74%.

Magnesium tablets were dissolved in anhydrous THF, and isobutyl bromine was dropped, and then reacted for 1h, and then anhydrous THF solution of compound (ⅰ) was added slowly, and then reflux for 4h, and cooled to room temperature. It was dropped into isopropyl alcohol solution of KBH4 and reflux for 4h. Cool, add water and extract with ethyl acetate. The extract was washed with water and saturated salt and dried. After filtration, the filtrate was decompressed and concentrated before distillation, and the fraction of 170℃/0.67kPa was collected to obtain compound (ⅱ) in 76% ~ 79% yield.